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Keywords:

  • drug delivery;
  • host–guest systems;
  • macrocyclic receptors;
  • mesoporous materials;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Dethreading of Cucurbit[7]uril CB[7]-based photoresponsive nanovalves utilizing biocompatible components that operate in water and biological media have been successfully constructed. The nanovalves employed tunable binding interactions between CB[7] rings and the cinnamamide stalks installed on the outer rim of mesoporous silica nanoparticles, and can be operated easily and effectively by irradiation with light (λ=300 nm), which induces a trans- to cis-conformational change of the cinnamamide stalks leading to the dethreading of CB[7]. For more details, see the Full Paper by Y.-W. Yang et al on page 9212 ff.