Macrocyclization of Oligoprolines
Despite the documented rigidity of homochiral oligoprolines, their macrocyclization could be forced with the help of zwitterionic control. The cyclization protocol proceeds within short reaction times and does not yield any oligomerization or polymerization byproducts. Cyclization of the zwitterionic intermediate in 2,2,2-trifluoroethanol is largely driven by the attractive electrostatic force of the two oppositely charged termini, the carboxylate and the isonitrilium ions. For more details, see the Communication on page 15612 ff., by A. K. Yudin et al.
Brain-derived neurotrophic factor (BDNF) is a protein essential for neuronal survival and axonal guidance. Its homeostasis is altered during different neurodegenerative disorders, in particular Alzheimer's disease. In their Full Paper on page 15618 D. La Mendola et al. show that a peptide representing the N-terminal region, BDNF(1–12), mimics the proliferative activity of the whole protein. The addition of Cu2+ induces a decrease in activity of both the peptide and the protein.
In their Full Paper on page 15662 ff., J. Huh, C. Park et al. demonstrate a simple, but robust self-assembly process for fabricating well-organized, nanoporous, ultrathin templates with control over both size and interdomain distance through conventional solution blending and spin-coating processes by using mono-end-sulfonated polystyrene (SPS)/mono-end-aminated poly(ethylene oxide) (APEO), for which SPS and APEO are reversibly end-associated.