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Biomimetic Ion Nanochannels as a Highly Selective Sequential Sensor for Zinc Ions Followed by Phosphate Anions

Authors

  • Dr. Cuiping Han,

    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
    2. School of Medical Imaging, Xuzhou Medical College, 209 Tong-shan Road, Xuzhou, Jiangsu, 221004 (P.R. China)
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  • Haiyan Su,

    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
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  • Zhongyue Sun,

    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
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  • Long Wen,

    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
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  • Demei Tian,

    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
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  • Prof. Kai Xu,

    1. School of Medical Imaging, Xuzhou Medical College, 209 Tong-shan Road, Xuzhou, Jiangsu, 221004 (P.R. China)
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  • Prof. Junfeng Hu,

    1. School of Medical Imaging, Xuzhou Medical College, 209 Tong-shan Road, Xuzhou, Jiangsu, 221004 (P.R. China)
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  • Prof. Aming Wang,

    1. School of Medical Imaging, Xuzhou Medical College, 209 Tong-shan Road, Xuzhou, Jiangsu, 221004 (P.R. China)
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  • Prof. Haibing Li,

    Corresponding author
    1. Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
    • Department Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China)
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  • Prof. Lei Jiang

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100191 (P.R. China)
    2. School of Chemistry & Environment, Beihang University, Beijing, 100190 (P.R. China)
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Abstract

A novel biomimetic ion-responsive multi-nanochannel system is constructed by covalently immobilizing a metal-chelating ligand, 2,2′-dipicolylamine (DPA), in polyporous nanochannels prepared in a polymeric membrane. The DPA-modified multi-nanochannels show specific recognition of zinc ions over other common metal ions, and the zinc-ion-chelated nanochannels can be used as secondary sensors for HPO42− anions. The immobilized DPA molecules act as specific-receptor binding sites for zinc ions, which leads to the highly selective zinc-ion response through monitoring of ionic current signatures. The chelated zinc ions can be used as secondary recognition elements for the capture of HPO42− anions, thereby fabricating a sensing nanodevice for HPO42− anions. The success of the DPA immobilization and ion-responsive events is confirmed by measurement of the X-ray photoelectron spectroscopy (XPS), contact angle (CA), and current–voltage (IV) characteristics of the systems. The proposed nanochannel sensing devices display remarkable specificity, high sensitivity, and wide dynamic range. In addition, control experiments performed in complex matrices suggest that this sensing system has great potential applications in chemical sensing, biotechnology, and many other fields.

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