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Keywords:

  • asymmetric catalysis;
  • enantioselectivity;
  • imines;
  • Mannich reactions;
  • pybox;
  • Yb(OTf)3
Thumbnail image of graphical abstract

Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox=pyridine bisoxazoline).