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Highly Efficient Catalytic Enantioselective Mannich Reaction of Malonates with N-tert-Butoxycarbonyl Imines by Using Yb(OTf)3/Pybox Catalysts at Room Temperature

Authors

  • Babak Karimi,

    Corresponding author
    1. Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-6731 (Iran), Fax: (+98) 241-415-3225
    • Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-6731 (Iran), Fax: (+98) 241-415-3225
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  • Ehsan Jafari,

    1. Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-6731 (Iran), Fax: (+98) 241-415-3225
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  • Dieter Enders

    1. Institüt für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen (Germany)
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Abstract

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Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox=pyridine bisoxazoline).

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