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Keywords:

  • amino esters;
  • cobalt;
  • domino reactions;
  • multicomponent reactions;
  • zinc
Thumbnail image of graphical abstract

Four in one: A straightforward synthesis of β2,3-amino esters is described through a new zinc-mediated, cobalt-catalyzed four-component reaction between organic bromides, alkyl acrylates, amines, and aldehydes (see scheme). Synthesis involves a Mannich-related conjugate addition/aza-aldol domino sequence, allowing the formation of three single bonds in one step. A reaction mechanism, emphasizing the crucial role of zinc salts, is described.