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A Ratiometric Fluorescent Probe for Biological Signaling Molecule H2S: Fast Response and High Selectivity

Authors

  • Jing Liu,

    1. School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
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    • These authors contributed equally to this work.

  • Yuan-Qiang Sun,

    1. School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
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    • These authors contributed equally to this work.

  • Jingyu Zhang,

    1. School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
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  • Ting Yang,

    1. Institute of Biotechnology, Shanxi University (P.R. China)
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  • Jianbin Cao,

    1. Research Institute of Applied Chemistry, Shanxi University (P.R. China)
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  • Lishen Zhang,

    1. School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
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  • Prof. Dr. Wei Guo

    Corresponding author
    1. School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
    • School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan 030006 (P.R. China), Fax: (+86) 351-7011600
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Abstract

original image

Selective and fast: A flavylium derivative-based ratiometric fluorescent probe (1) for H2S is reported. The reaction mechanism (see scheme) is based on the nucleophilic addition of H2S towards the electrically positive benzopyrylium moiety of 1, which can efficiently differentiate H2S from other competitive species. The probe exhibits a fast response toward H2S, within 10 s, which is superior to most of the reported H2S probes.

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