Dynamic Multivalency for Carbohydrate–Protein Recognition through Dynamic Combinatorial Libraries Based on FeII–Bipyridine Complexes

Authors

  • Philipp Reeh,

    1. The Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007-Tarragona (Spain)
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  • Prof. Javier de Mendoza

    Corresponding author
    1. The Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007-Tarragona (Spain)
    • The Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007-Tarragona (Spain)
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Abstract

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Molecular recognition: Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate–protein recognition. The interaction of a three-component DCL based on 2,2′-bipyridine (bipy)–FeII complexes with concanavalin A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose-containing library components.

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