TaMe3Cl2-Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope

Authors

  • Dr. Zhengxing Zhang,

    1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Institution, Vancouver, BC, V6T 1Z1 (Canada)
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  • Jean-Denys Hamel,

    1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Institution, Vancouver, BC, V6T 1Z1 (Canada)
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  • Prof. Dr. Laurel L. Schafer

    Corresponding author
    1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Institution, Vancouver, BC, V6T 1Z1 (Canada)
    • Department of Chemistry, University of British Columbia, 2036 Main Mall, Institution, Vancouver, BC, V6T 1Z1 (Canada)
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Abstract

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Tantalizingly simple: The common organometallic starting material TaMe3Cl2 can be used for the catalytic C[BOND]H functionalization reaction, hydroaminoalkylation. The substrate scope for this readily accessed compound includes unactivated terminal and internal alkenes, styrene derivatives, and both alkylaryl- and dialkyl secondary amines (see scheme).

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