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Sequential Norrish Type II Photoelimination and Intramolecular Aldol Cyclization of α-Diketones: Synthesis of Polyhydroxylated Cyclopentitols by Ring Contraction of Hexopyranose Carbohydrate Derivatives

Authors

  • Dr. Dimitri Alvarez-Dorta,

    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
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  • Dr. Elisa I. León,

    Corresponding author
    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
    • Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135

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  • Dr. Alan R. Kennedy,

    1. WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (UK)
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  • Dr. Angeles Martín,

    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
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  • Dr. Inés Pérez-Martín,

    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
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  • Dr. Concepción Riesco-Fagundo,

    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
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  • Prof. Dr. Ernesto Suárez

    Corresponding author
    1. Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135
    • Instituto de Productos Naturales, y Agrobiología del C.S. I.C. Carretera de la Esperanza 3, 38203 La Laguna, Tenerife (Spain), Fax: (+34) 922-260-135

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Abstract

The excitation of the innermost carbonyl of nono-2,3-diulose derivatives by irradiation with visible-light initiates a sequential Norrish type II photoelimination and aldol cyclization process that finally gives polyfunctionalized cyclopentitols. The rearrangement has been confirmed by the isolation of stable acyclic photoenol intermediates that can be independently cyclized by a thermal 5-(enolexo)-exo-trig uncatalyzed aldol reaction with high diastereoselectivity. In this last step, the large deuterium kinetic isotope effect found for the 1,5-hydrogen atom transfer seems to indicate that the aldol reaction runs through a concerted pericyclic mechanism. Owing to the ready availability of pyranose sugars of various configurations, this protocol has been used to study the influence of pyranose ring-substituents on the diastereoselectivity of the aldol cyclization reaction. In contrast with other pyranose ring contraction methodologies no transition-metal reagents are needed and the sequential rearrangement occurs simply by using visible light and moderate heating (0 to 60 °C).

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