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Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromxya salina

Authors

  • Stephan Felder,

    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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  • Dr. Sandra Dreisigacker,

    1. Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany)
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  • Dr. Stefan Kehraus,

    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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  • Edith Neu,

    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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  • Prof. Dr. Gabriele Bierbaum,

    1. Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn (Germany)
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  • Patrick R. Wright,

    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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  • Prof. Dr. Dirk Menche,

    1. Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany)
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  • Dr. Till F. Schäberle,

    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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  • Prof. Dr. Gabriele M. König

    Corresponding author
    1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
    • Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49) 228-733250
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Abstract

Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven-membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes.

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