The Redox-Neutral Approach to C[BOND]H Functionalization

Authors

  • Dr. Bo Peng,

    1. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 2083062974
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  • Dr. Nuno Maulide

    Corresponding author
    1. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 2083062974
    • Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 2083062974

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Abstract

The direct functionalization of C[BOND]H bonds is an attractive strategy in organic synthesis. Although several advances have been made in this area, the selective activation of inert sp3 C[BOND]H bonds remains a daunting challenge. Recently, a new type of sp3 C[BOND]H activation mode through internal hydride transfer has demonstrated the potential to activate remote sp3 C[BOND]H linkages in an atom-economic manner. This Minireview attempts to classify recent advances in this area including the transition to non-activated sp3 C[BOND]H bonds and asymmetric hydride transfers.

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