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A Cascade Coupling Strategy for One-Pot Total Synthesis of β-Carboline and Isoquinoline-Containing Natural Products and Derivatives

Authors

  • Dr. Yan-Ping Zhu,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
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  • Mei-Cai Liu,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
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  • Qun Cai,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
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  • Feng-Cheng Jia,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
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  • Prof. An-Xin Wu

    Corresponding author
    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
    • Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (P. R. China), Fax: (+86) 27-6786-7773
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Abstract

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Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme).

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