Ruthenium-Catalyzed Transfer-Hydrogenative Cyclization of 1,6-Diynes with Hantzsch 1,4-Dihydropyridine as a H2 Surrogate

Authors

  • Prof. Dr. Yoshihiko Yamamoto,

    Corresponding author
    1. Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan), Fax: (+81) 52 747 6800
    • Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan), Fax: (+81) 52 747 6800
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  • Shota Mori,

    1. Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan), Fax: (+81) 52 747 6800
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  • Dr. Masatoshi Shibuya

    1. Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan), Fax: (+81) 52 747 6800
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Abstract

The transfer-hydrogenative cyclization of 1,6-diynes with Hantzsch 1,4-dihydropyridine as a H2 surrogate was performed in the presence of a cationic ruthenium catalyst of the type [Cp′Ru(MeCN)3PF6]. Exocyclic 1,3-dienes or their 1,4-hydrogenation products, cycloalkenes, were selectively obtained, depending on the substrate structure and the reaction conditions.

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