Paraldehyde as an Acetaldehyde Precursor in Asymmetric Michael Reactions Promoted by Site-Isolated Incompatible Catalysts

Authors

  • Xinyuan Fan,

    1. Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona (Spain), Fax: (+34) 977-920-243
    Search for more papers by this author
  • Dr. Carles Rodríguez-Escrich,

    1. Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona (Spain), Fax: (+34) 977-920-243
    Search for more papers by this author
  • Dr. Sonia Sayalero,

    1. Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona (Spain), Fax: (+34) 977-920-243
    Search for more papers by this author
  • Prof. Dr. Miquel A. Pericàs

    Corresponding author
    1. Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona (Spain), Fax: (+34) 977-920-243
    2. Departament de Química Orgànica, Universitat de Barcelona, 08080 Barcelona (Spain)
    • Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona (Spain), Fax: (+34) 977-920-243
    Search for more papers by this author

Abstract

original image

A song of ice and fire! The usually innocent paraldehyde can be used as an acetaldehyde precursor in an organocatalytic asymmetric Michael addition (see scheme) thanks to the proper combination of two immobilized catalysts. The site isolation induced by the polymeric supports has proven crucial to preclude deactivation of the otherwise incompatible catalysts.

Ancillary