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Rhodium-Catalyzed Directed Sulfenylation of Arene C[BOND]H Bonds

Authors

  • Dr. Yaxi Yang,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
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    • These authors contributed equally to this work.

  • Dr. Wei Hou,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
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    • These authors contributed equally to this work.

  • Lihuai Qin,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
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  • Dr. Juanjuan Du,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
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  • Huijin Feng,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
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  • Dr. Bing Zhou,

    Corresponding author
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)

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  • Dr. Yuanchao Li

    Corresponding author
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (PR China)

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Abstract

The rhodium-catalyzed intermolecular direct C[BOND]H thiolation of arenes with aryl and alkyl disulfides was developed for the first time to provide a convenient route to aryl thioethers. This strategy is compatible with many different directing groups and exhibits excellent functional group tolerance. More significantly, mono- or dithiolation can be selectively achieved, thus providing a straightforward way for selective preparation of aryl thioethers and dithioethers.

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