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Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors

Authors

  • Yue Zhou,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)
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  • Li-Li Tan,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)
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  • Qing-Lan Li,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)
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  • Xi-Long Qiu,

    1. College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193 (P.R. China)
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  • Prof. Ai-Di Qi,

    1. College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193 (P.R. China)
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  • Yanchun Tao,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)
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  • Prof. Ying-Wei Yang

    Corresponding author
    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)
    • State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China)

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Abstract

Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene- or pillarene-based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof-of-concept study is far from a real-life application, it provides a possible route to treat diseases related to the central nervous system.

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