Hourglass-like Ni(OH)2 nanostructures were selected to serve as electrode modifiers to demonstrate the correlation between the structure of nanomaterials and their electrocatalytic activity on L-histidine. All three types of Ni(OH)2 nanostructure-modified electrodes have a lower detection limit and wider linear range than the commercial materials. The electrocatalytic activity of these unique nanostructures was found to not only depend on their external architecture, but also on their relevant internal degree of crystallinity. These findings may enable the design of new and better electrocatalytic materials by using shape-controlled nanoparticles. For more details see the Full Paper by Li and Guo et al. on page 501 ff.