Cover Picture: The Role of a Dipeptide Outer-Coordination Sphere on H2-Production Catalysts: Influence on Catalytic Rates and Electron Transfer (Chem. Eur. J. 6/2013)



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Dipeptide-based ligands on Ni(P2N2)2 hydrogen production catalysts can alter both the rate and the overpotential of the resulting catalyst. The figure shows an overlay of the trajectories from molecular dynamics simulations and highlights the flexibility of the dipeptide ligands, which may aid in transient delivery of protons, but also limits the precise positioning achieved in enzymes. For more details see the Full Paper by S. Raugei, J. A. S. Roberts, W. J. Shaw and co-workers on page 1928 ff.

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Organolithium Compounds

A flow microreactor system consisting of micromixers and microtube reactors has been used as an effective tool for the generation and reactions of either laterally lithiated aziridines or tetrahydroisoquinoline lithiated at C4, depending on the reaction temperature. A thermally induced isomerization process has been tamed by exquisite thermal control realized in the flow microreactor system. Trapping with electrophiles such organolithium intermediates gave access to functionalized aziridines and tetrahydroisoquinolines. Details of these interesting processes are described in the Communication by J.-i. Yoshida, R. Luisi and co-workers on page 1872 ff.

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Molecular interactions between sugars and G-quadruplex DNA structures are observed in different carbohydrate G-quadruplex conjugates. Mono- and disaccharides are covalently linked to the 5′ end of oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)) and their thermal stability and structure in solution have been studied by using UV and NMR spectroscopy and molecular dynamics. Saccharides and the DNA bases from the TGT loop of the TBA quadruplex actually compete for interacting with the guanine tetrad. CH/π stacking, hydrogen bonding, and hydrophobic contacts play a role in the interaction between carbohydrates and the DNA G-tetrad. For more details, see the Full Paper by C. Gonzalez and J. C. Morales and co-workers on page 1919 ff.

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Reduction of Graphene Oxide

Upon the reduction of graphene oxide by using ethanethiol–aluminum chloride complexes, the reduced material exhibits improved electrochemical properties over its precursor graphite oxide. This selective reduction opens up new opportunities for specific tailoring of graphene materials. For more information see the Full Paper by M. Pumera and C. K. Chua on page 2005 ff.

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