Multiple Bond-Forming Transformations
1,2- and 1,3-dicarbonyl compounds are exceptional synthetic platforms that are particularly well adapted for multiple bond-forming transformations (MBFTs). These powerful sequences are highlighted in the Concept Article by the Rodriguez group on page 2218 ff. Domino, multicomponent, and consecutive reactions with these powerful and densely functionalized building blocks have allowed the stereoselective preparation of very diverse and complex molecular architectures with the formation of up to six chemical bonds under efficient step- and atom-economical conditions.
In their Communication on page 2232 ff. J. Keiser, G. Gasser et al. demonstrate that two easy-to-prepare chromium tricarbonyl praziquantel (PZQ) derivatives achieve an impressive antischistosomal effect (nanomolar range) on adult S. mansoni in vitro. Importantly, these compounds were shown to be safe when tested using two distinct cell lines and had remarkable selectivity for the adult stage of S. mansoni that lives in the portal and mesenteric vein system of the human host.
A facile and general carbonization and extraction procedure to prepare a series of nitrogen-doped carbon dots (N-Cdots) with different nitrogen contents is proposed by X.-B. Yin et al. in their Full Paper on page 2276 ff. They found that Cdots exist in core–shell structures with a graphite core and a loose oxygen-containing-group shell. PL emission from the N-Cdots was observed to have nitrogen-content-dependent intensities with multicolor and two-photon upconverted properties. The merits of doped Cdots make them potential probes in optical imaging and sensing applications.