Cover Picture: Histone-Deacetylase-Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents (Chem. Eur. J. 31/2013)

Authors

  • Rui-Rong Ye,

    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
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  • Dr. Zhuo-Feng Ke,

    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
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  • Dr. Cai-Ping Tan,

    Corresponding author
    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
    • MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245

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  • Liang He,

    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
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  • Prof. Liang-Nian Ji,

    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
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  • Prof. Dr. Zong-Wan Mao

    Corresponding author
    1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245
    • MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (P. R. China), Fax: (+86) 20-8411-2245

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Abstract

original image

Fluorescent ruthenium complexes have been used as inhibitors of histone deacetylases (HDACs). In their Full Paper on page 10160 ff., Z.-W Mao, C.-P. Tan, and co-workers report a series of red fluorescent ruthenium(II) complexes that can inhibit HDAC and induce apoptotic cell death in tumor cells. These fluorescent RuII-HDACi conjugates represent a promising class of anticancer agents for potential dual imaging and therapeutic applications targeting HDACs (cover graphic by Mu-Qiang Wei).

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