Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin–Gold Nanoparticles

Authors

  • Sharbari Palmal,

    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India)
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  • Amit Ranjan Maity,

    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India)
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  • Brijesh Kumar Singh,

    1. National Brain Research Centre, Manesar, Gurgaon-122050 (India)
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  • Sreetama Basu,

    1. National Brain Research Centre, Manesar, Gurgaon-122050 (India)
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  • Prof. Nihar R. Jana,

    Corresponding author
    1. National Brain Research Centre, Manesar, Gurgaon-122050 (India)
    • Nihar R. Jana, National Brain Research Centre, Manesar, Gurgaon-122050 (India)

      Nikhil R. Jana, Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India)

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  • Dr. Nikhil R. Jana

    Corresponding author
    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India)
    • Nihar R. Jana, National Brain Research Centre, Manesar, Gurgaon-122050 (India)

      Nikhil R. Jana, Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata-700032 (India)

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Abstract

Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10–25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.

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