A Magnetically Drivable Nanovehicle for Curcumin with Antioxidant Capacity and MRI Relaxation Properties

Authors

  • Massimiliano Magro,

    1. Department of Comparative Biomedicine and Food Safety, Agripolis - University of Padua, Legnaro, 35020 Padua (Italy)
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  • René Campos,

    1. Department of Chemistry and Biochemistry, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo (Brazil)
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  • Davide Baratella,

    1. Department of Comparative Biomedicine and Food Safety, Agripolis - University of Padua, Legnaro, 35020 Padua (Italy)
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  • Giuseppina Lima,

    1. Department of Chemistry and Biochemistry, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo (Brazil)
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  • Katerina Holà,

    1. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
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  • Clemens Divoky,

    1. Institute of Medical Engineering, Graz University of Technology, 8010 Graz (Austria)
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  • Rudolf Stollberger,

    1. Institute of Medical Engineering, Graz University of Technology, 8010 Graz (Austria)
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  • Ondrej Malina,

    1. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
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  • Claudia Aparicio,

    1. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
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  • Giorgio Zoppellaro,

    1. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
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  • Prof. Radek Zbořil,

    Corresponding author
    1. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
    • Radek Zbořil, Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)

      Fabio Vianello, Department of Comparative Biomedicine and Food Safety, Agripolis - University of Padua, Legnaro, 35020 Padua (Italy)

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  • Prof. Fabio Vianello

    Corresponding author
    1. Department of Comparative Biomedicine and Food Safety, Agripolis - University of Padua, Legnaro, 35020 Padua (Italy)
    2. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)
    • Radek Zbořil, Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Palacky University, Olomouc (Czech Republic)

      Fabio Vianello, Department of Comparative Biomedicine and Food Safety, Agripolis - University of Padua, Legnaro, 35020 Padua (Italy)

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Abstract

Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (γ-Fe2O3), called surface-active maghemite nanoparticles (SAMNs) were surface-modified with curcumin molecules, due to the presence of under-coordinated FeIII atoms on the nanoparticle surface. The so-obtained curcumin-modified SAMNs (SAMN@curcumin) had a mean size of 13±4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mössbauer spectroscopy, X-ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.

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