Total Synthesis of Phorboxazole B (pages 1185–1204)
De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu, Ce Su, Wei-Shan Zhou and Guo-Qiang Lin
Version of Record online: 3 NOV 2005 | DOI: 10.1002/chem.200500892
21-Membered macrolides: Ranked among the most cytostatic natural products ever known, phorboxazole B (see scheme) represents a new class of 21-membered macrolides. Herein we report an efficient and convergent total synthesis of this compound.