Transmission of Binding Information across Lipid Bilayers (pages 7215–7222)
Harmen P. Dijkstra, Jordan J. Hutchinson, Christopher A. Hunter, Haiyuan Qin, Salvador Tomas, Simon J. Webb and Nicholas H. Williams
Article first published online: 19 JUN 2007 | DOI: 10.1002/chem.200601723
Transmembrane communication: A synthetic transmembrane receptor system transmits molecular information across a lipid bilayer by cooperative binding events on the inside and outside of vesicle membranes (see graphic). An extravesicular binding event induces receptor aggregation, resulting in enhanced copper(II) binding to intravesicular aggregated ligand sites.