Total Synthesis of Myxovirescin A1 (pages 8762–8783)
Alois Fürstner, Melanie Bonnekessel, Jarred T. Blank, Karin Radkowski, Günter Seidel, Fabrice Lacombe, Barbara Gabor and Richard Mynott
Article first published online: 4 SEP 2007 | DOI: 10.1002/chem.200700926
A convergent total synthesis of the antibiotic macrolide myxovirescin A1 is described that is largely based on reagent- and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of a dibromo-alkene, a palladium-catalyzed alkyl-Suzuki coupling, an exquisitely selective ring-closing alkyne metathesis, and a ruthenium-catalyzed trans-hydrosilylation tandem.