DNA Binding by a New Metallointercalator that Contains a Proflavine Group Bearing a Hanging Chelating Unit (pages 184–196)
Carla Bazzicalupi, Andrea Bencini, Antonio Bianchi, Tarita Biver, Alessia Boggioni, Sara Bonacchi, Andrea Danesi, Claudia Giorgi, Paola Gratteri, Antonio Marchal Ingraín, Fernando Secco, Claudia Sissi, Barbara Valtancoli and Marcella Venturini
Version of Record online: 13 SEP 2007 | DOI: 10.1002/chem.200601855
A new proflavine-based intercalator and its ZnII complex form DNA adducts according to intercalative and groove-binding processes, as shown by means of spectroscopic methods and stopped-flow measurements. Molecular modelling studies support both binding processes and provide evidence for the influence of NH+⋅⋅⋅O interactions between the protonated acridine nitrogen and the oxygen atoms of the polyanion; this promotes the formation of DNA adducts in which the intercalator penetrates perpendicularly to the base pair hydrogen bonds (see picture).