Chemistry - A European Journal

Cover image for Vol. 14 Issue 25

August 28, 2008

Volume 14, Issue 25

Pages 7387–7719

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
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    1. Cover Picture: XAS and XMCD Investigation of Mn12 Monolayers on Gold (Chem. Eur. J. 25/2008) (page 7387)

      Matteo Mannini, Philippe Sainctavit, Roberta Sessoli, Christophe Cartier dit Moulin, Francesco Pineider, Marie-Anne Arrio, Andrea Cornia and Dante Gatteschi

      Version of Record online: 25 AUG 2008 | DOI: 10.1002/chem.200890097

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      An eye for molecules on a surface. In the Full Paper by D. Gatteschi et al. on page 7530 ff., synchrotron light has been employed to investigate the chemical and magnetic nature of monolayers of sulfur-functionalized Mn12 clusters grafted on gold substrates to reveal significant reduction of the manganese atoms and the disappearance of the typical magnetic hysteresis.

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
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    1. You have free access to this content
      Turin: A European Experience—Take Two (pages 7388–7391)

      Neville Compton

      Version of Record online: 25 AUG 2008 | DOI: 10.1002/chem.200801617

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
    9. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
    9. Preview
  5. Concepts

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
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    1. Palladium Catalysts

      Development of Palladium–Carbene Catalysts for Telomerization and Dimerization of 1,3-Dienes: From Basic Research to Industrial Applications (pages 7408–7420)

      Nicolas D. Clement, Lucie Routaboul, Anne Grotevendt, Ralf Jackstell and Matthias Beller

      Version of Record online: 4 AUG 2008 | DOI: 10.1002/chem.200800858

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      From test tubes to pilot plants: A personal account on more than ten years of research concerning telomerisation and dimerisation reactions (see scheme) is presented. The development of N-heterocyclic carbene based palladium catalysts is highlighted that have been applied on industrial pilot-plant scale.

    2. Dendrimers

      Dendrimers and DNA: Combinations of Two Special Topologies for Nanomaterials and Biology (pages 7422–7432)

      Anne-Marie Caminade, Cédric-Olivier Turrin and Jean-Pierre Majoral

      Version of Record online: 9 JUN 2008 | DOI: 10.1002/chem.200800584

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      Precious interactions: Combinations of dendrimers and DNA are described as well as the various aspects of the interactions: a) DNA can be the structural constituent of dendrimers; b) dendrimers can be used as 3D linkers for improving the sensitivity of biosensors; and c) dendrimers are efficient vectors of DNA to penetrate inside cells through electrostatic interactions, in view of genetic therapy.

    3. Oligosaccharide Mimics

      Interfering with the Sugar Code: Design and Synthesis of Oligosaccharide Mimics (pages 7434–7441)

      Anna Bernardi and Pavel Cheshev

      Version of Record online: 9 JUL 2008 | DOI: 10.1002/chem.200800597

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      Sweet mimicry: This short overview covers recent efforts towards design and synthesis of glycomimetic inhibitors (three examples of which are shown here) of well-known target lectins (cholera toxin, DC-SIGN).

    4. Supramolecular Chemistry

      Dye-Modified Nanochannel Materials for Photoelectronic and Optical Devices (pages 7442–7449)

      Gion Calzaferri, Huanrong Li and Dominik Brühwiler

      Version of Record online: 14 JUL 2008 | DOI: 10.1002/chem.200800811

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      Standing in line: The alignment of dye molecules in the channels of zeolite L can be extended to the macroscopic scale by preparing monolayers of crystals with defined morphology (see graphic). Systems including multiple types of dye monomers form the basis for the design of novel device architectures in the field of optical and photoelectronic applications.

    5. Microreactors

      Flash Chemistry: Fast Chemical Synthesis by Using Microreactors (pages 7450–7459)

      Jun-ichi Yoshida, Aiichiro Nagaki and Takeshi Yamada

      Version of Record online: 9 JUN 2008 | DOI: 10.1002/chem.200800582

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      Speedy reaction: Flash chemistry is defined as a field of chemical synthesis in which extremely fast reactions are conducted in a highly controlled manner to produce desired compounds with high selectivity. This article provides a brief outline of the concept of flash chemistry using microreactors and its applications to organic synthesis and polymer synthesis.

    6. Carbometalation

      A Shift in Retrosynthetic Paradigm (pages 7460–7468)

      Ilan Marek

      Version of Record online: 18 JUN 2008 | DOI: 10.1002/chem.200800580

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      How to improve efficiency! The one-pot transformation of various alkynyl derivatives into functionalized homoallylic alcohols and amines (see scheme) can be easily performed through a combination of carbometalation, zinc homologation, and allylation reactions.

    7. Chemical Engineering

      Enabling Continuous-Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine-Chemical Production (pages 7470–7477)

      Norbert Kockmann, Michael Gottsponer, Bertin Zimmermann and Dominique M. Roberge

      Version of Record online: 9 JUL 2008 | DOI: 10.1002/chem.200800707

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      Go with the flow: Chemical reactions in continuous-flow microstructured devices (see graphic) are described by fluid dynamics, transport phenomena and reaction kinetics. They enable the investigation of complex chemical reactions in the laboratory and the low-risk scale-up to high production rates.

    8. Mesoporous Materials

      Textural Manipulation of Mesoporous Materials for Hosting of Metallic Nanocatalysts (pages 7478–7488)

      Junming Sun and Xinhe Bao

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200800823

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      Chemically significant mesoporous materials with tunable pore size and pore length could be controlled effectively. Monodisperse metal nanoparticles with tunable particles size have been encapsulated within the mesoporous materials (see graphic) by various strategies, especially by a facile autoreduction route.

    9. Glyco Chemistry

      Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins (pages 7490–7499)

      Anne Imberty, Yoann M. Chabre and René Roy

      Version of Record online: 10 JUL 2008 | DOI: 10.1002/chem.200800700

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      Sugars against sticky bacteria: A panel of glycomolecules (an example of which is shown here) for the inhibition of bacterial adhesion on host glycoconjugates is described.

  6. Communications

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
    9. Preview
    1. Electron Transfer

      Synthesis of New Hybrid Hydroquinone/Cobalt Schiff Base Catalysts: Efficient Electron-Transfer Mediators in Aerobic Oxidation (pages 7500–7503)

      Byron W. Purse, Lien-Hoa Tran, Julio Piera, Björn Åkermark and Jan-Erling Bäckvall

      Version of Record online: 4 JUL 2008 | DOI: 10.1002/chem.200800657

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      Cultivating hybrids: The synthesis of new hybrid aerobic oxidation catalysts that include an oxygen-activating motif and a hydroquinone is reported. These hybrid catalysts proved to be efficient for the aerobic reoxidation of palladium and ruthenium catalysts in a set of test oxidations (see graphic).

    2. Organocatalysis

      Diversity-Oriented Synthesis towards Conceptually New Highly Modular Aminal–Pyrrolidine Organocatalysts (pages 7504–7507)

      Adrien Quintard, Chloée Bournaud and Alexandre Alexakis

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200801212

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      New family member: A conceptually new family of modular aminal–pyrrolidine organocatalysts was prepared by diversity-oriented synthesis. The catalytic properties of these organocatalysts could easily be tuned by varying the different substituents on the aminal part. Good yields and enantioselectivities up to 91 % were obtained in Michael additions to nitroolefins or vinyl sulfones (see scheme).

    3. Fischer Carbenes

      C[BOND]H Insertion Processes on Stabilized Indolyl and ortho-Aminophenyl Fischer Carbene Complexes: Synthesis of Azepino[3,2,1-hi] indole, Benzazepine and Indole Derivatives (pages 7508–7512)

      José Barluenga, Martín Fañanás-Mastral and Fernando Aznar

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200801132

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      A new sequential [n+2] cycloaddition/C[BOND]H insertion reaction of indolylalkynyl and ortho-aminophenylalkynyl Fischer carbene complexes that leads to azepino[3,2,1-hi]indole, benzazepine, and indole derivatives is described. As an extension of this chemical behavior, 1,2-disubstituted indoles can be obtained from methoxy ortho-aminophenyl Fischer carbene complexes (see scheme).

    4. Hydrogenation

      Highly Chemo- and Enantioselective Hydrogenation of Linear α,β-Unsaturated Ketones (pages 7513–7516)

      Sheng-Mei Lu and Carsten Bolm

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200801096

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      Highly chemo- and enantioselective hydrogenations of linear β,β-disubstituted enones (see scheme) have been accomplished by using iridium complexes 1 ai bearing chiral sulfoximine-type P,N-ligands. The catalyst system preferentially hydrogenates the C[DOUBLE BOND]C double bonds giving saturated ketones as the major products. Substrates with bulky substituents at the β-position give the best enantioselectivities. Thus, enones with isopropyl and cyclohexyl substituents afford ketones with 97 % ee (at >95 % conversion).

    5. Drug Interactions

      Specific Methyl Group Protonation for the Measurement of Pharmacophore-Specific Interligand NOE Interactions (pages 7517–7520)

      Julien Orts, S. Kaspar Grimm, Christian Griesinger, K. Ulrich Wendt, Stefan Bartoschek and Teresa Carlomagno

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200800880

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      Pharmacophore signature at glance: INPHARMA NOE interactions can be measured between two ligands that bind competitively to a common macromolecular receptor, and can be interpreted quantitatively to derive the binding mode of the two ligands. This approach relies on computationally demanding full relaxation matrix calculations. Here we demonstrate that the INPHARMA NOEs measured in the presence of a selectively-protonated receptor (see figure) can be interpreted in a semiquantitative way to discriminate between binding poses, thus relieving for the need of demanding computations.

    6. Vitamin B12

      A Crystalline B12 Dimer from β-Cyano-Neocobyrate (pages 7521–7524)

      Shahzad Murtaza, Philipp Butler, Christoph Kratky, Karl Gruber and Bernhard Kräutler

      Version of Record online: 4 AUG 2008 | DOI: 10.1002/chem.200800809

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      To dimerize or not to dimerize: The crystal structure of β-cyano-neocobyric acid reveals a new vitamin B12 dimerization motif (see figure) that involves α-face interactions and Co-coordinated f-propionate side chains. This motif is reminiscent of the carboxylate-bonded heme dimer in β-haematin and hemozoin, the disposal form of heme in Plasmodium malaria.

    7. Sensors

      AND/NOT Sensing of Fluoride and Cyanide Ions by Ferrocene-Derivatised Lewis Acids (pages 7525–7529)

      Alexander E. J. Broomsgrove, David A. Addy, Christopher Bresner, Ian A. Fallis, Amber L. Thompson and Simon Aldridge

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200801381

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      A simple two-component sensor system was developed, featuring the strongly Lewis acidic (but air-stable) FcRBMes2 (1: FcR=(η5-C5H4)Fe(η5-C5R5), R=H, Me; Mes=2,4,6-Me3C6H2), which can be shown to bind both fluoride AND cyanide in solution (but not other anions), and the weaker boronic ester Lewis acid FcRB(OR)2 (2: (OR)2=R,R-OC(H)PhC(H)PhO), which signals the presence of fluoride but NOT cyanide in solution. By coupling the electrochemical shifts with a suitable redox-active tetrazolium dye, a colorimetric AND/NOT sensor system for fluoride and cyanide ions can be developed (see picture).

  7. Full Papers

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
    9. Preview
    1. Molecular Magnets

      XAS and XMCD Investigation of Mn12 Monolayers on Gold (pages 7530–7535)

      Matteo Mannini, Philippe Sainctavit, Roberta Sessoli, Christophe Cartier dit Moulin, Francesco Pineider, Marie-Anne Arrio, Andrea Cornia and Dante Gatteschi

      Version of Record online: 9 JUL 2008 | DOI: 10.1002/chem.200800693

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      Cold experiments: The first low temperature XAS/XMCD study of Mn12 adsorbates on gold reveals an intrinsic redox-instability of the clusters (see figure) and highlights the potential of the XAS/XMCD technique to probe the behaviour of molecular magnets at surfaces.

    2. Olefin Metathesis

      Ruthenium–Olefin Complexes: Effect of Ligand Variation upon Geometry (pages 7536–7544)

      Donde R. Anderson, Daniel J. O'Leary and Robert H. Grubbs

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/chem.200701362

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      Different bearings: A series of Ru–olefin complexes bearing different L-type ligands were synthesized and characterized by NMR spectroscopy and X-ray crystallography. Only evidence for side-bound isomers was observed (see graphic).

    3. Homogeneous Catalysis

      Ruthenium-Based Olefin Metathesis Catalysts Coordinated with Unsymmetrical N-Heterocyclic Carbene Ligands: Synthesis, Structure, and Catalytic Activity (pages 7545–7556)

      Georgios C. Vougioukalakis and Robert H. Grubbs

      Version of Record online: 21 JUL 2008 | DOI: 10.1002/chem.200800470

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      The next generation: A series of ruthenium-based metathesis catalysts bearing unsymmetrical N-heterocyclic carbene ligands were synthesized and fully characterized. Their catalytic activity was evaluated in a variety of benchmark ring-closing metathesis, ring-opening metathesis polymerization, and cross metathesis reactions (see figure). The electronic properties of the new carbenes were also studied in the corresponding [Rh(CO)2Cl(NHC)] complexes.

    4. Molecular Recognition

      The Bound Conformation of Microtubule-Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin (pages 7557–7569)

      Angeles Canales, Ruth Matesanz, Nicola M. Gardner, José Manuel Andreu, Ian Paterson, J. Fernando Díaz and Jesús Jiménez-Barbero

      Version of Record online: 30 APR 2008 | DOI: 10.1002/chem.200800039

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      Conformation analysis: NMR experiments followed by a docking procedure have allowed the microtubule-bound conformations of discodermolide (DDM) and dictyostatin (DCT), two microtubule-stabilizing agents, to be deduced. Superimpositions of the NMR-derived bound conformers of DDM (yellow) and DCT (violet) on paclitaxel (green) are shown. According to these models, paclitaxel provides additional contacts with tubulin by using the extended side chain.

    5. Aromatic–Carbohydrate Interactions: An NMR and Computational Study of Model Systems (pages 7570–7578)

      Sophie Vandenbussche, Dolores Díaz, María Carmen Fernández-Alonso, Weidong Pan, Stéphane P. Vincent, Gabriel Cuevas, Francisco Javier Cañada, Jesús Jiménez-Barbero and Kristin Bartik

      Version of Record online: 15 MAY 2008 | DOI: 10.1002/chem.200800247

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      Recognition of simple sugars, with different stereochemistries, by aromatic entities (such as depicted), including phenol and the aromatic amino acids, has been studied by NMR (chemical shift perturbations, NOE experiments) assisted by molecular mechanics and DFT calculations, as model systems for naturally occurring protein–carbohydrate interactions.

    6. Molecular Modelling

      Metallobiological Necklaces: Mass Spectrometric and Molecular Modeling Study of Metallation in Concatenated Domains of Metallothionein (pages 7579–7593)

      Jayna Chan, Zuyun Huang, Ian Watt, Peter Kille and Martin Stillman

      Version of Record online: 4 AUG 2008 | DOI: 10.1002/chem.200800787

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      Metallothionein necklaces: Electrospray mass spectrometry of concatenated Cd4S11 domains (an example of which is depicted here) shows differential demetallation that can be interpreted by molecular dynamics calculations.

    7. Organometallic Radicals

      Selective C[BOND]C Coupling of Ir–Ethene and Ir–Carbenoid Radicals (pages 7594–7599)

      Wojciech I. Dzik, Joost N. H. Reek and Bas de Bruin

      Version of Record online: 3 JUN 2008 | DOI: 10.1002/chem.200800262

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      A carbenoid–radical intermediate is responsible for formation of a C3-bridged dinuclear iridium species upon reaction of a mononuclear IrII–ethene complex with ethyl diazoacetate in MeCN. The analogous reaction with trimethylsilyldiazomethane leads to a mononuclear IrIII–CH2SiMe3 species through hydrogen-atom abstraction.

    8. Supramolecular Chemistry

      Functionalized Supramolecular Nanoporous Arrays for Surface Templating (pages 7600–7607)

      Luís M. A. Perdigão, Alex Saywell, Giselle N. Fontes, Paul A. Staniec, Gudrun Goretzki, Anna G. Phillips, Neil R. Champness and Peter H. Beton

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200800476

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      Keeping functional groups at bay: The introduction of functional groups to the “bay” region of perylene tetracarboxylic diimides significantly influences surface-based self-assembly processes leading to either unimolecular or bimolecular hexagonal surface networks, exploiting either homo- or hetero-molecular hydrogen bonding.

    9. Redox Chemistry

      Characterization of Three Members of the Electron-Transfer Series [Fe(pda)2]n (n=2−, 1−, 0) by Spectroscopy and Density Functional Theoretical Calculations [pda=Redox Non-innocent Derivatives of N,N′-Bis(pentafluorophenyl)-o-phenylenediamide(2−, 1.−, 0)] (pages 7608–7622)

      Marat M. Khusniyarov, Eckhard Bill, Thomas Weyhermüller, Eberhard Bothe, Klaus Harms, Jörg Sundermeyer and Karl Wieghardt

      Version of Record online: 7 JUL 2008 | DOI: 10.1002/chem.200800546

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      Iron complexes with non-innocent ligands: The detailed investigation of the electronic structures of a series of iron complexes with redox active o-phenylenediamide(2−) derived ligands by means of crystallography, magnetochemistry, spectroscopic methods, and density functional calculations is presented. [FeIII(L.−)(L2−)] (SFe=3/2; St=1) possesses the depicted electronic structure with delocalized ligand mixed valency.

    10. Controlled Radical Polymerization

      Cobalt-Mediated Radical Polymerization of Acrylonitrile: Kinetics Investigations and DFT Calculations (pages 7623–7637)

      Antoine Debuigne, Catherine Michaux, Christine Jérôme, Robert Jérôme, Rinaldo Poli and Christophe Detrembleur

      Version of Record online: 15 JUL 2008 | DOI: 10.1002/chem.200800371

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      Controlling polymerization: Experimental and computational studies show how solvent coordination can fine-tune the [CoII(acac)2] system for the synthesis of well-controlled poly(acrylonitrile) (PAN) and poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) block copolymers (see scheme).

    11. Donor–Acceptor Systems

      One-Electron-Reduced and -Oxidized Stages of Donor-Substituted 1,1,4,4-Tetracyanobuta-1,3-dienes of Different Molecular Architectures (pages 7638–7647)

      Milan Kivala, Tsvetanka Stanoeva, Tsuyoshi Michinobu, Brian Frank, Georg Gescheidt and François Diederich

      Version of Record online: 18 JUL 2008 | DOI: 10.1002/chem.200800716

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      Spin and charge confinement: One-electron-reduced and -oxidized stages of donor-substituted 1,1,4,4-tetracyanobuta-1,3-dienes (TCBDs) were generated by chemical methods and studied by using EPR spectroscopy (see figure). In radical anions, confinement of spin and charge to the electron-withdrawing TCBD moieties was observed. In radical cations, an analogous charge and spin localization to the electron-donating moieties was found.

    12. Asymmetric Catalysis

      Dinuclear Zinc-Catalyzed Asymmetric Desymmetrization of Acyclic 2-Substituted-1,3-Propanediols: A Powerful Entry into Chiral Building Blocks (pages 7648–7657)

      Barry M. Trost, Sushant Malhotra, Takashi Mino and Naomi S. Rajapaksa

      Version of Record online: 24 JUL 2008 | DOI: 10.1002/chem.200800623

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      Catalytic asymmetric desymmetrization: The dinuclear zinc-catalyzed asymmetric desymmetrization of acyclic 2-substituted-1,3-propanediols provides several 2-alkyl-, 2-alkoxy-, and 2-aryl-1,3-propanediols (see scheme). Further elaboration of the products provides several useful chiral building blocks for natural product synthesis.

    13. Thin Films

      Optical Properties of Hybrid Dendritic–Mesoporous Titania Nanocomposite Films (pages 7658–7669)

      Eugenia Martínez-Ferrero, Grégory Franc, Serge Mazères, Cédric-Olivier Turrin, Cédric Boissière, Anne-Marie Caminade, Jean-Pierre Majoral and Clément Sanchez

      Version of Record online: 30 JUL 2008 | DOI: 10.1002/chem.200800606

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      Sense and sensitivity: The immobilisation of fluorescent dendrimers improves their sensing properties. Fluorescent dendrimers show enhanced selectivity towards hazardous phenolic compounds after being grafted onto mesoporous titania films and have potential applications as sensors (see graphic). This effect is a result of the increased spatial proximity of the fluorescent molecules, which is induced by pore confinement.

    14. Donor–Acceptor Systems

      Screening Electronic Communication through ortho-, meta- and para-Substituted Linkers Separating Subphthalocyanines and C60 (pages 7670–7679)

      David González-Rodríguez, Tomás Torres, María Ángeles Herranz, Luis Echegoyen, Esther Carbonell and Dirk M. Guldi

      Version of Record online: 15 JUL 2008 | DOI: 10.1002/chem.200800910

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      Tuning communication: The effect of ortho, meta and para isomeric connections on the electronic communication between subphthalocyanine and C60 in molecular systems that can give rise to energy- or electron-transfer mechanisms (see graphic) have been analyzed.

    15. Rhodium Complexes

      Spin State, Structure, and Reactivity of Terminal Oxo and Dioxygen Complexes of the (PNP)Rh Moiety (pages 7680–7686)

      Alexander Y. Verat, Hongjun Fan, Maren Pink, Y.-S. Chen and Kenneth G. Caulton

      Version of Record online: 4 AUG 2008 | DOI: 10.1002/chem.200800573

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      Triplets! A functional equivalent of [Rh{(tBu2PCH2SiMe2)2N}] reacts with N2O to give [RhO(PNP)], which has a triplet ground state. The related dioxygen complex was also investigated (see picture).

    16. Epoxidation

      Biomimetic Iron-Catalyzed Asymmetric Epoxidation of Aromatic Alkenes by Using Hydrogen Peroxide (pages 7687–7698)

      Feyissa Gadissa Gelalcha, Gopinathan Anilkumar, Man Kin Tse, Angelika Brückner and Matthias Beller

      Version of Record online: 20 JUN 2008 | DOI: 10.1002/chem.200800595

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      Benzyl makes the difference! The N-benzyl-substituted (S,S)-1 is the key to the realization of the title reaction, in which the asymmetric epoxidation of aromatic alkenes with aqueous hydrogen peroxide proceeds smoothly at room temperature in the presence of simple Fe salts and pyridine-2,6-dicaroxylic acid (H2(pydic)).

    17. Asymmetric Hydrogenation

      A Multilateral Mechanistic Study into Asymmetric Transfer Hydrogenation in Water (pages 7699–7715)

      Xiaofeng Wu, Jianke Liu, Devis Di Tommaso, Jonathan A. Iggo, C. Richard A. Catlow, John Bacsa and Jianliang Xiao

      Version of Record online: 4 JUL 2008 | DOI: 10.1002/chem.200800559

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      The mechanism of aqueous-phase asymmetric transfer hydrogenation (see scheme) of acetophenone with HCOONa catalyzed by Ru-TsDPEN has been investigated by stoichiometric reactions, NMR probing, kinetic and isotope effect measurements, DFT modeling, and X-ray structure analysis.

  8. Preview

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Graphical Abstract
    5. News
    6. Concepts
    7. Communications
    8. Full Papers
    9. Preview
    1. You have free access to this content
      Preview: Chem. Eur. J. 26/2008 (page 7719)

      Version of Record online: 25 AUG 2008 | DOI: 10.1002/chem.200890100

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