A Phosphotyrosine-Imprinted Polymer Receptor for the Recognition of Tyrosine Phosphorylated Peptides (pages 9516–9529)
Marco Emgenbroich, Cristiana Borrelli, Sudhirkumar Shinde, Issam Lazraq, Filipe Vilela, Andrew J. Hall, Joakim Oxelbark, Ersilia De Lorenzi, Julien Courtois, Anna Simanova, Jeroen Verhage, Knut Irgum, Kal Karim and Börje Sellergren
Article first published online: 10 OCT 2008 | DOI: 10.1002/chem.200801046
A useful marker: An epitope-imprinting strategy leads to a synthetic phosphotyrosine-selective imprinted polymer receptor. Urea-mediated imprinting of N,O-protected phosphotyrosine (see picture) leads to a synthetic receptor capable of selectively extracting phosphotyrosine peptides in the presence of phosphoserine, phosphothreonine, and non-phosphorylated peptides.