Chemistry - A European Journal

Cover image for Chemistry - A European Journal

April 6, 2009

Volume 15, Issue 15

Pages 3623–3903

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Corrigendum
    5. News
    6. Concept
    7. Communications
    8. Full Papers
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    1. Cover Picture: Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch-On Probes for Practical Application in Protein Staining and Cell Imaging (Chem. Eur. J. 15/2009) (page 3623)

      Peng Wu, Ella Lai-Ming Wong, Dik-Lung Ma, Glenna So-Ming Tong, Kwan-Ming Ng and Chi-Ming Che

      Version of Record online: 26 MAR 2009 | DOI: 10.1002/chem.200990048

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      Photoluminescent cyclometalated platinum(II) complexes can bind non-covalently and non-specifically towards various proteins and such bonding is accompanied by a dramatic increase in the intensity of photoluminescence in the visible spectral region. It can be practically applied for staining protein mixtures in 1D and 2D SDS-PAGE, giving emissive gel images directly under UV light without any de-staining procedures. For more information see the Communication by C.-M. Che et al. on page 3652 ff. (SDS-PAGE=sodium dodecyl sulfate polyarcylamide gel electrophoresis).

  2. Graphical Abstract

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  3. Corrigendum

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    1. You have free access to this content
      Aluminium Speciation in 1-Butyl-1-Methylpyrrolidinium Bis(trifluoromethylsulfonyl)amide/AlCl3 Mixtures (page 3632)

      Nathalie M. Rocher, Ekaterina I. Izgorodina, Theo Rüther, Maria Forsyth, Douglas R. MacFarlane, Thomas Rodopoulos, Michael D. Horne and Alan M. Bond

      Version of Record online: 26 MAR 2009 | DOI: 10.1002/chem.200990050

      This article corrects:

      Aluminium Speciation in 1-Butyl-1-Methylpyrrolidinium Bis(trifluoromethylsulfonyl)amide/AlCl3 Mixtures

      Vol. 15, Issue 14, 3435–3447, Version of Record online: 8 JAN 2009

  4. News

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  5. Concept

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    1. Liquid Crystals

      Star Mesogens (Hekates)—Tailor-Made Molecules for Programming Supramolecular Functionality (pages 3638–3651)

      Matthias Lehmann

      Version of Record online: 9 MAR 2009 | DOI: 10.1002/chem.200802625

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      Hekates: Modular synthesis of star-shaped molecules affords mesogens with various functional units and incompatible peripheral chains (see figure). The supramolecular order in the complex, soft, liquid-crystalline, functional materials can be programmed by variation of the elements of diversity at a meso- and nanoscale.

  6. Communications

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    1. Luminescent Protein Stains

      Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch-On Probes for Practical Application in Protein Staining and Cell Imaging (pages 3652–3656)

      Peng Wu, Ella Lai-Ming Wong, Dik-Lung Ma, Glenna So-Ming Tong, Kwan-Ming Ng and Chi-Ming Che

      Version of Record online: 9 FEB 2009 | DOI: 10.1002/chem.200802707

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      Protein-staining platinum: The luminescent switch-on characteristic of the platinum(II) complex can be utilized for staining a series of proteins in sodium dodecyl sulfate-polyarcylamide gels, to give emissive gel images directly under UV light (see figure). The detection sensitivity for BSA protein is down to 6.0 ng, revealing potential practical applications of luminescent platinum(II) complexes in the luminescent signaling of biomolecules.

    2. Photodeformative Liquid Crystal

      Light-Induced Deformation of Photoresponsive Liquid Crystals on a Water Surface (pages 3657–3660)

      Kunihiko Okano, Masato Shinohara and Takashi Yamashita

      Version of Record online: 27 FEB 2009 | DOI: 10.1002/chem.200802461

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      Photodeformation: Azobenzene derivatives showing a room-temperature liquid crystal (LC) phase exhibit photoinduced deformation on a water surface. While a droplet of a LC sample floating on the surface expands upon UV irradiation, a LC sample containing a solvent is condensed towards the center of the illuminated regions (see figure).

    3. Magnetic Properties

      An End-On Azide-Bridged Antiferromagnetic Single-Chain Magnet Involving Spin Canting and Field-Induced Two-Step Magnetic Transitions (pages 3661–3665)

      Jung Hee Yoon, Dae Won Ryu, Hyoung Chan Kim, Sung Won Yoon, Byoung Jin Suh and Chang Seop Hong

      Version of Record online: 9 MAR 2009 | DOI: 10.1002/chem.200900250

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      Two-step magnetic transitions: An azide-bridged 1D MnIII coordination polymer with a unique single end-on mode was prepared; it displayed atypical antiferromagnetic couplings and field-induced two-step magnetic transitions (see figure). The spin-canted phenomenon in the antiferromagnetic chain complex plays a pivotal role in establishing the slow magnetic relaxation.

    4. Cross-Coupling Reactions

      Synthesis of Aryl Sulfides by Decarboxylative C[BOND]S Cross-Couplings (pages 3666–3669)

      Zhongyu Duan, Sadananda Ranjit, Pengfei Zhang and Xiaogang Liu

      Version of Record online: 26 FEB 2009 | DOI: 10.1002/chem.200900133

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      Without the need for organohalide precursors, the convenient and general synthesis of aryl (or diaryl) sulfides can be achieved by using aryl carboxylic acids and thiols or disulfides for decarboxylative C[BOND]S cross-coupling catalyzed by a bimetallic system (see scheme).

    5. Biphasic Catalysis

      Enhanced Pd-Catalyzed Hydrogenation of Olefins within Polymeric Microreactors under Organic/Aqueous Biphasic Conditions (pages 3670–3673)

      Yang Lan, Minchao Zhang, Wangqing Zhang and Li Yang

      Version of Record online: 26 FEB 2009 | DOI: 10.1002/chem.200802697

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      A microreactor of hollow polymeric microspheres with Pd nanoparticles immobilized in its wall is designed for hydrogenation of olefins under organic/aqueous biphasic catalysis. The microreactor has an ability to encapsulate and concentrate olefins within the vacancy of the hollow microspheres in the aqueous phase, and therefore hydrogenation within the microreactors runs efficiently with concentrated reactants under organic/aqueous biphasic condition (see scheme).

    6. C[BOND]C Coupling

      Fluorescent Diarylindoles by Palladium-Catalyzed Direct and Decarboxylative Arylations of Carboxyindoles (pages 3674–3677)

      Mitsuru Miyasaka, Azusa Fukushima, Tetsuya Satoh, Koji Hirano and Masahiro Miura

      Version of Record online: 26 FEB 2009 | DOI: 10.1002/chem.200900098

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      Simple and brilliant: 1-Substituted 1H-indole-2-carboxylic acids efficiently undergo successive diarylation accompanied by C[BOND]H bond cleavage and decarboxylation upon treatment with aryl bromides in the presence of a palladium catalyst system to afford fluorescent 2,3-diarylindoles. This facile synthetic method provides a highly efficient blue emitter with a quantum yield of 0.97 in the solid state (see scheme).

    7. Asymmetric Catalysis

      A N,N′-Dioxide–Copper(II) Complex as an Efficient Catalyst for the Enantioselective and Diastereoselective Mannich-Type Reaction of Glycine Schiff Bases with Aldimines (pages 3678–3681)

      Deju Shang, Yanling Liu, Xin Zhou, Xiaohua Liu and Xiaoming Feng

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200900118

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      Mild mannered! A highly diastereo- and enantioselective Mannich-type reaction of glycine Schiff base 1 has been developed by using the N,N′-dioxide L-CuII complex as a catalyst. Various optically active anti-α,β-diamino acid esters were obtained in good yields with up to 96:4 d.r. and 97 % ee. This straightforward method features a low catalyst loading and mild reaction conditions.

  7. Full Papers

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Corrigendum
    5. News
    6. Concept
    7. Communications
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    1. Electronic Communication

      Linker Conjugation Effects in Rhenium(I) Bifunctional Hole-Transport/Emitter Molecules (pages 3682–3690)

      Deidre M. Cleland, Garth Irwin, Pawel Wagner, David L. Officer and Keith C. Gordon

      Version of Record online: 5 MAR 2009 | DOI: 10.1002/chem.200802373

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      Interchromophoric communicationwhen darkness falls: This study investigates the electronic communication between various hole-transporting (HT) ligands and a rhenium(phenanthroline) centre to which they are coordinated. It is found that when the conjugation within the HT ligand is increased, the energy of a non-emissive HT ligand electronic transition is sufficiently lowered so that it interacts with, and partially deactivates, emission from the rhenium(phenanthroline) moiety (see figure).

    2. Molecular Tweezers

      Self-Assembly of Bis(merocyanine) Tweezers into Discrete Bimolecular π-Stacks (pages 3691–3705)

      Andreas Lohr, Matthias Grüne and Frank Würthner

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802391

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      Dipolar aggregation: Examples of a novel class of tweezer molecules have been constructed through the tethering of two dipolar merocyanine chromophores. The electrostatic-interaction-directed self-assembly of these tweezers affords centrosymmetric bimolecular complexes with a unique aggregate geometry of four π-stacked chromophores (see picture) with an alternating arrangement of their dipole moments and very high dimerization constants, even in the good solvating solvent chloroform.

    3. Supramolecular Chemistry

      Solvent-Assisted Organized Structures Based on Amphiphilic Anion-Responsive π-Conjugated Systems (pages 3706–3719)

      Hiromitsu Maeda, Yoshihiro Ito, Yohei Haketa, Nazuki Eifuku, Eunji Lee, Myongsoo Lee, Takeshi Hashishin and Kenji Kaneko

      Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802152

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      Just subtract water: Amphiphilic π-conjugated acyclic oligopyrroles form solvent-assisted H-aggregates that give rise to vesicular structures in aqueous solution (see figure). The H-aggregates are sensitive to the conditions and are transformed into J-aggregates by the removal of water.

    4. Sensors

      Responsive Metal Complexes: A Click-Based “Allosteric Scorpionate” Complex Permits the Detection of a Biological Recognition Event by EPR/ENDOR Spectroscopy (pages 3720–3728)

      Emiliano Tamanini, Stephen E. J. Rigby, Majid Motevalli, Matthew H. Todd and Michael Watkinson

      Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802425

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      Click to detect! Azamacrocyclic complexes with a triazole scorpion ligand may be easily assembled, as shown for a biotin-functionalised cyclam derivative. Coordination of the triazole to the metal is perturbed by the binding of avidin to the pendant ligand (see scheme). This event can be sensitively detected with EPR and ENDOR spectroscopy, which confirm the loss of the axial triazole nitrogen donor upon avidin binding. This general strategy may have wide applications in imaging and therapeutics.

    5. Self-Assembly

      Construction of Helical J-Aggregates Self-Assembled from a Thymidylic Acid Appended Anthracene Dye and DNA as a Template (pages 3729–3735)

      Rika Iwaura, Mayumi Ohnishi-Kameyama and Tomohiko Iizawa

      Version of Record online: 10 FEB 2009 | DOI: 10.1002/chem.200802537

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      Driven round the twist by DNA: One-dimensional helical J-aggregates are formed by the self-assembly of thymidylic acid appended anthracene dye (shown in red and yellow) in the presence of complementary single-stranded oligoadenylic acid (shown in green and blue) in an aqueous solution.

    6. Organofluorosilanes

      Organofluorosilanes as Model Compounds for 18F-Labeled Silicon-Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography) (pages 3736–3743)

      Aileen Höhne, Lian Yu, Linjing Mu, Markus Reiher, Ulrike Voigtmann, Ulrich Klar, Keith Graham, P. August Schubiger and Simon M. Ametamey

      Version of Record online: 6 MAR 2009 | DOI: 10.1002/chem.200802437

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      Water stable! Radiochemists have recently discovered silicon chemistry as a tool for the introduction of 18F into biomolecules for positron emission tomography (PET) imaging. 18F-labeled PET tracers must be stable towards defluorination under physiological conditions. Here, a theoretical model of organofluorosilane hydrolysis is developed that correlates with the experimentally determined hydrolytic half-lives and allows estimation of the stability of newly designed compounds (see scheme).

    7. Porphyrins

      Application of the Perimeter Model to the Assignment of the Electronic Absorption Spectra of Gold(III) Hexaphyrins with [4n+2] and [4n] π-Electron Systems (pages 3744–3751)

      Atsuya Muranaka, Osamu Matsushita, Kengo Yoshida, Shigeki Mori, Masaaki Suzuki, Taniyuki Furuyama, Masanobu Uchiyama, Atsuhiro Osuka and Nagao Kobayashi

      Version of Record online: 11 FEB 2009 | DOI: 10.1002/chem.200801742

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      Expanded porphyrins: The electronic excited states of two forms of meso-hexakis(pentafluorophenyl)-substituted gold(III) hexaphyrin(1.1.1.1.1.1), such as that depicted, have been investigated by density functional calculations and magnetic circular dichroism spectroscopy to assign their low-energy excited singlet states.

    8. Hydrogen Storage

      Selective Formic Acid Decomposition for High-Pressure Hydrogen Generation: A Mechanistic Study (pages 3752–3760)

      Céline Fellay, Ning Yan, Paul J. Dyson and Gábor Laurenczy

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801824

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      A viable storage system for hydrogen based on selective formic acid decomposition into H2 and CO2 has been developed (see scheme). Continuous generation of H2 of very high purity, over a wide range of pressures and under mild conditions was achieved.

    9. Metalloproteins

      The Correlation of 113Cd NMR and 111mCd PAC Spectroscopies Provides a Powerful Approach for the Characterization of the Structure of CdII-Substituted ZnII Proteins (pages 3761–3772)

      Olga Iranzo, Tamas Jakusch, Kyung-Hoon Lee, Lars Hemmingsen and Vincent L. Pecoraro

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802105

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      The powerful combination of 113Cd NMR and 111mCd PAC (perturbed angular correlation) spectroscopies has been critical to determine the coordination geometry of CdII bound to thiolate-rich centers. We have obtained important linear correlations between 113Cd NMR and 111mCd PAC spectroscopic data and the acid/base properties of the metal binding site that illustrate the presence of a dynamic model for metal binding (see figure). These unique results can give new insight into CdII-substituted ZnII proteins.

    10. Polymerization

      On the Initiation Mechanism of Syndiospecific Styrene Polymerization Catalyzed by Single-Component ansa-Lanthanidocenes (pages 3773–3783)

      Lionel Perrin, Yann Sarazin, Evgueni Kirillov, Jean-François Carpentier and Laurent Maron

      Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802036

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      Single-site catalysts: Syndiospecific styrene polymerization promoted by single-site ansa-lanthanidocene catalysts proceeds selectively in a secondary (2,1) fashion, both at the initiation and propagation steps. The steric hindrance between the phenyl ring of the incoming styrene monomer and the ancillary ligands (Cp′, Flu′), induced by the change of either the bridge or the “active” R ligand in the catalyst precursor, is proposed to control the reactivity of the complexes (see scheme).

    11. Cyclopropanation

      First Example of Highly Stereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes via Chiral Selenonium Ylides (pages 3784–3789)

      Hai-Yang Wang, Fei Yang, Xin-Liang Li, Xue-Ming Yan and Zhi-Zhen Huang

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801936

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      A new strategy for the highly stereoselective synthesis of three stereoisomers of chiral 1,2,3-trisubstituted cyclopropanes in good yields with excellent diastereoselectivities and very high enantioselectivities (up to >99 % ee) was developed via selenonium ylides (see scheme). Possible pathways for the asymmetric cyclopropanations were also proposed.

    12. Amine Alkylation

      Selective Iridium-Catalyzed Alkylation of (Hetero)Aromatic Amines and Diamines with Alcohols under Mild Reaction Conditions (pages 3790–3799)

      Benoît Blank, Stefan Michlik and Rhett Kempe

      Version of Record online: 13 FEB 2009 | DOI: 10.1002/chem.200802318

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      Selective amine alkylation: A P,N-ligand-stabilized iridium complex has been used as an efficient catalyst for the alkylation of (hetero)aromatic amines with alcohols at mild reaction temperatures and catalyst loadings as low as 0.1 mol % Ir (see scheme). The excellent selectivity of the catalyst for monoalkylation of the amine function has also been exploited for the N,N′-dialkylation of diamines in both symmetric and nonsymmetric fashions.

    13. Selective Zincation

      You have full text access to this OnlineOpen article
      Synthetic and Structural Insights into the Zincation of Toluene: Direct Synergic Ring Metallation versus Indirect Nonsynergic Lateral Metallation (pages 3800–3807)

      David R. Armstrong, Joaquín García-Álvarez, David V. Graham, Gordon W. Honeyman, Eva Hevia, Alan R. Kennedy and Robert E. Mulvey

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801928

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      Unprecedented direct zincation of toluene can be achieved by using a bimetallic base that bypasses the acidic methyl group and instead affords a statistical mixture of the meta and para deprotonated regioisomers (see scheme).

    14. Aldol Addition Reactions

      D-Fructose-6-phosphate Aldolase in Organic Synthesis: Cascade Chemical-Enzymatic Preparation of Sugar-Related Polyhydroxylated Compounds (pages 3808–3816)

      Alda Lisa Concia, Carles Lozano, José A. Castillo, Teodor Parella, Jesús Joglar and Pere Clapés

      Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802532

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      D-Fructose-6-phosphate aldolase (FSA) is a key biocatalyst for the alternative synthetic construction of biologically active products with known therapeutic and research interest or novel structures relevant to drug discovery. Novel aldol addition reactions of dihydroxyacetone and hydroxyacetone to a variety of aldehydes catalyzed by FSA are presented (see scheme).

    15. Carbonylation Reactions

      Rhodium(I)-Catalyzed Reductive Cyclocarbonylation of Internal Alkynes: Atom-Economic Process for Synthesis of 2-Cyclopenten-1-ones, 5-Alkylidenefuran-2(5 H)-ones and Indan-1-ones (pages 3817–3822)

      Qiufeng Huang and Ruimao Hua

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802462

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      Economical atoms: 2-Cyclopenten-1-ones, 5-alkylidenefuran-2(5 H)-ones and indan-1-ones have been synthesized by atom-economic reductive cyclocarbonylation of internal alkynes with carbon monoxide catalyzed by [{RhCl(CO)2}2]/CO(NH2)2 in the presence of water (see scheme).

    16. Reaction Mechanisms

      Acceleration of Reductive Elimination of [Ar-Pd-Cmath image] by a Phosphine/Electron-Deficient Olefin Ligand: A Kinetic Investigation (pages 3823–3829)

      Heng Zhang, Xiancai Luo, Kittiya Wongkhan, Hui Duan, Qiang Li, Lizheng Zhu, Jian Wang, Andrei S. Batsanov, Judith A. K. Howard, Todd B. Marder and Aiwen Lei

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802209

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      Dramatic rate enhancement of reductive elimination of [Ar-Pd-Cmath image] was observed in the presence of a phosphine/electron-deficient olefin ligand. Through systematic kinetic investigations of the Negishi coupling of ethyl 2-iodobenzoate with alkylzinc chlorides (see scheme), the rate constants for reductive elimination of [Ar-Pd-Cmath image] were determined to be greater than 0.3 s−1, which is about four or five orders of magnitude greater than values reported previously.

    17. Coordination Polymers

      Novel Molecular Building Blocks Based on the Boradiazaindacene Chromophore: Applications in Fluorescent Metallosupramolecular Coordination Polymers (pages 3830–3838)

      Ö. Altan Bozdemir, Onur Büyükcakir and Engin U. Akkaya

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802538

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      Bright polymers: Fluorescent coordination polymers made up of versatile functionalized bodipy (boron-dipyrrin) chromophore building blocks, such as that depicted, are described. Polymerization is signaled by changes in fluorescence emission intensity and shifts in peak emission wavelengths.

    18. Peptide Modification

      Electron-Deficient Alkynes as Cleavable Reagents for the Modification of Cysteine-Containing Peptides in Aqueous Medium (pages 3839–3850)

      Hoi-Yan Shiu, Tak-Chung Chan, Chi-Ming Ho, Yungen Liu, Man-Kin Wong and Chi-Ming Che

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200800669

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      Enriched cleavage: An efficient chemoselective cysteine modification of unprotected peptides and proteins has been developed by using electron-deficient alkynes in aqueous media. Interestingly, terminal alkynone-modified peptides could be converted back into the unmodified peptides by cleavage by adding thiols under mild conditions (see scheme).

    19. Nanodiamonds

      Reactivities of the Prism-Shaped Diamondoids [1(2)3]Tetramantane and [12312]Hexamantane (Cyclohexamantane) (pages 3851–3862)

      Andrey A. Fokin, Boryslav A. Tkachenko, Natalie A. Fokina, Heike Hausmann, Michael Serafin, Jeremy E. P. Dahl, Robert M. K. Carlson and Peter R. Schreiner

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801867

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      Functionalized nanodiamonds: Various functional groups have been incorporated into the structures of the naturally occurring diamondoids [1(2)3]tetramantane and [12312]hexamantane (cyclohexamantane), which represent hydrogen-terminated prism-shaped nanodiamonds (see picture). The attachment points define the use of these diamond-like molecules as geometric building blocks for a variety of applications.

    20. Conformational Analysis

      The Nature and Sequence of the Amino Acid Aglycone Strongly Modulates the Conformation and Dynamics Effects of Tn Antigen's Clusters (pages 3863–3874)

      Francisco Corzana, Jesús H. Busto, Marisa García de Luis, Jesús Jiménez-Barbero, Alberto Avenoza and Jesús M. Peregrina

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801777

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      All in a cluster: The selected sequence has a crucial influence on both the orientation and flexibility of the carbohydrate moiety in mucin-type glycopeptides (see picture). This feature can be explained through the varied conformational behavior of the glycosidic linkage of the Thr residue when compared with the Ser residue (see figure). On this basis, and taking into account that these carbohydrates presumably interact with components of the immune system, these findings could be helpful in the design of new cancer vaccines.

    21. Cascade Reactions

      Lewis Acid Catalyzed Cascade Reactions of 1,6-Diynes and 1,6-Enynes with Vinylidenecyclopropanes (pages 3875–3881)

      Liang-Feng Yao and Min Shi

      Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802284

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      Cascade reactions: Lewis acid catalyzed cascade reactions of 1,6-diynes and 1,6-enynes with arylvinylidenecyclopropanes produce polycyclic compounds and isopropylidene-3,3-diarylcyclobut-1-enylmethyl derivatives (see scheme) in good to high yields along with a PtCl2-catalyzed cyclization and a Cu(OAc)2H2O-catalyzed Eglinton coupling reaction.

    22. Carbon Nanotubes

      Carbon Nanotube–Acridine Nanohybrids: Spectroscopic Characterization of Photoinduced Electron Transfer (pages 3882–3888)

      Nicolas Mackiewicz, Jacques A. Delaire, A. William Rutherford, Eric Doris and Charles Mioskowski

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200801863

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      Change happens: Acridine–carbon nanotube nanohybrids were built (see figure) and their photoinduced electron-transfer properties investigated, showing variable behaviour depending on the acridine partner.

    23. Pincer Ligands

      Nickel Complexes of a Pincer Amidobis(amine) Ligand: Synthesis, Structure, and Activity in Stoichiometric and Catalytic C[BOND]C Bond-Forming Reactions of Alkyl Halides (pages 3889–3899)

      Oleg Vechorkin, Zsolt Csok, Rosario Scopelliti and Xile Hu

      Version of Record online: 19 FEB 2009 | DOI: 10.1002/chem.200802059

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      Get a grip! NiII complexes of the new pincer amidobis(amine) ligand are described. The Ni chloride complex catalyzes Kumada–Corriu–Tamao coupling of unactivated alkyl halides with alkyl Grignard reagents, as well as double C–C coupling of CH2Cl2 with alkyl Grignard reagents (see schemes).

  8. Preview

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    3. Graphical Abstract
    4. Corrigendum
    5. News
    6. Concept
    7. Communications
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    1. You have free access to this content
      Preview: Chem. Eur. J. 16/2009 (page 3903)

      Version of Record online: 26 MAR 2009 | DOI: 10.1002/chem.200990052

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