Chemistry - A European Journal

Cover image for Vol. 16 Issue 13

April 6, 2010

Volume 16, Issue 13

Pages 3867–4133

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
    9. Full Papers
    10. Preview
    1. Cover Picture: A Conjugated Thiophene-Based Rotaxane: Synthesis, Spectroscopy, and Modeling (Chem. Eur. J. 13/2010) (page 3867)

      Leszek Zalewski, Michael Wykes, Sergio Brovelli, Massimo Bonini, Thomas Breiner, Marcel Kastler, Florian Dötz, David Beljonne, Harry L. Anderson, Franco Cacialli and Paolo Samorì

      Article first published online: 26 MAR 2010 | DOI: 10.1002/chem.201090057

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      A rigid rotaxane based on dithiophene and β-cyclodextrin (CD), as shown in the cover picture, and its shape-persistent corresponding dumbbell are discussed by L. Zalewski, D. Beljonne, H. L. Anderson, F. Cacialli, P. Samorì et al. in their Full Paper on page 3933 ff. In addition to the synthesis and characterization of both systems, they have elucidated the excited-state dynamics and the effect of cyclodextrin encapsulation, as well as finding that β-CD is a very mobile macrocycle. This work was supported by ESF-SONS2.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
    9. Full Papers
    10. Preview
    1. Inside Cover: A Triphenylphosphonium-Functionalised Cyclometalated Platinum(II) Complex as a Nucleolus-Specific Two-Photon Molecular Dye (Chem. Eur. J. 13/2010) (page 3868)

      Chi-Kin Koo, Leo K.-Y. So, Ka-Leung Wong, Yu-Man Ho, Yun-Wah Lam, Michael H.-W. Lam, Kwok-Wai Cheah, Chopen Chan-Wut Cheng and Wai-Ming Kwok

      Article first published online: 26 MAR 2010 | DOI: 10.1002/chem.201090058

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      An organelle specific imaging agent has been synthesized from a cyclometalated platinum complex. The organelle specificity and two-photon-induced luminescent properties renders it a useful two-photon nuclear dye for the 3D reconstruction of optical sections of thick tissues. For more details see the Full Paper by Y.-W. Lam, M. H.-W. Lam et al. on page 3942 ff.

  3. Graphical Abstract

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    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
    9. Full Papers
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  4. Corrigendum

    1. Top of page
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    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
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    1. You have free access to this content
      Reactivity and Regioselectivity of Noble Gas Endohedral Fullerenes Ng@C60 and Ng2@C60 (Ng=He–Xe) (page 3878)

      S. Osuna, M. Swart and M. Solà

      Article first published online: 26 MAR 2010 | DOI: 10.1002/chem.201090060

      This article corrects:

      Reactivity and Regioselectivity of Noble Gas Endohedral Fullerenes Ng@C60 and Ng2@C60 (Ng=He–Xe)

      Vol. 15, Issue 47, 13111–13123, Article first published online: 26 OCT 2009

  5. News

    1. Top of page
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    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
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  6. Review

    1. Top of page
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    1. Total Synthesis

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      Syntheses of Fumagillin and Ovalicin (pages 3884–3901)

      Junichiro Yamaguchi and Yujiro Hayashi

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.200902433

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      Strategic planning! This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of this family that are known angiogenesis inhibitors. Despite the relatively small size of these molecules, their syntheses highlight the efficient construction of stereogenic centers in organic synthesis (see scheme).

  7. Communications

    1. Top of page
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    4. Graphical Abstract
    5. Corrigendum
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    1. Natural Products

      Naphthospironone A: An Unprecedented and Highly Functionalized Polycyclic Metabolite from an Alkaline Mine Waste Extremophile (pages 3902–3905)

      Zhang-Gui Ding, Ming-Gang Li, Jiang-Yuan Zhao, Jie Ren, Rong Huang, Ming-Jin Xie, Xiao-Long Cui, Hua-Jie Zhu and Meng-Liang Wen

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.200903198

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      Bring in the new: Naphthospironone A (1), a novel polycyclic metabolite with an unprecedented spiro[bicyclo[3.2.1]octene-pyran]dione ring system, was isolated from alkalophilic Nocardiopsis sp. (YIM DT266). Its complete structural assignment with the absolute stereochemistry was elucidated by spectroscopic data, X-ray crystal diffraction, and calculation of optical rotation by using DFT methods. Naphthospironone A exhibited moderate cytotoxic and antibiotic bioactivities.

    2. Cross-Coupling Reactions

      Low-Temperature Ag/Pd-Catalyzed Decarboxylative Cross-Coupling of Aryl Triflates with Aromatic Carboxylate Salts (pages 3906–3909)

      Lukas J. Gooßen, Paul P. Lange, Nuria Rodríguez and Christophe Linder

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.200903319

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      At 50°C lower than the best known copper catalysts, a catalytic silver(I)/palladium(II) system allows the decarboxylative cross-coupling of arenecarboxylates with aryl triflates at temperatures as low as 120 °C. Remarkably, polychlorinated and many heterocyclic arenecarboxylates are converted for the first time in high yields. FG=functional group.

    3. Heterogeneous Catalysis

      [PdCl2(MeCN)2]-Catalyzed Highly Regio- and Stereoselective Allylation of Electron-Rich Arenes with 2,3-Allenoates (pages 3910–3913)

      Zhao Fang, Chunling Fu and Shengming Ma

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.200903012

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      Selective allylation: Several electron-donating arenes such as 1,3,5-trimethoxybenzene, anisole, and phenol underwent palladium-catalyzed selective allylation in TFA/dimethylacetamide (DMA) under mild conditions with 2,3-allenoates (see scheme). The reaction afforded substituted 4,4-diarylbut-2(E)-enoates in moderate yields with high regio- and stereoselectivity.

    4. Fluorescent Probes

      Coumarin-Caged Rosamine Probes Based on a Unique Intramolecular Carbon–Carbon Spirocyclization (pages 3914–3917)

      Weiying Lin, Lingliang Long, Wen Tan, Bingbing Chen and Lin Yuan

      Article first published online: 10 MAR 2010 | DOI: 10.1002/chem.201000015

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      Caged fluorophore: We report the first caging strategy for rosamine fluorophores based on a unique intramolecular carbon–carbon spirocyclization. The new class of carbon–carbon spirocyclic caged probes exhibit several significant advantages over the traditional nitrobenzyl-caged xanthene probes and can be employed for spatially controlled fluorescence imaging of living cells (see graphic).

    5. Asymmetric Synthesis

      Enantioenrichment by Iterative Retro-Aldol/Aldol Reaction Catalyzed by an Achiral or Racemic Base (pages 3918–3921)

      Angelika M. Flock, Christine M. M. Reucher and Carsten Bolm

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.200903497

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      Did nature use the same strategy? The combination of crystal growth and iterative retro-aldol/aldol reactions catalyzed by a simple achiral (or racemic) base allows improvement of the enantiomer ratio of a product obtained from a stereochemically imperfect aldol reaction (see scheme).

    6. Asymmetric Catalysis

      Multiple-Organocatalyst-Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted Piperidines (pages 3922–3925)

      Yao Wang, De-Feng Yu, Yao-Zong Liu, Hao Wei, Yong-Chun Luo, Darren J. Dixon and Peng-Fei Xu

      Article first published online: 5 MAR 2010 | DOI: 10.1002/chem.201000059

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      Multiple reactions in a single pot: The development of a catalytic asymmetric approach to fully substituted piperidines, which previously remained elusive, is achieved by the use of a multi-catalyst-promoted cascade reaction (see scheme). The one-pot reaction cascade is easy to perform, highly stereoselective and broad in scope, and the reaction products are high-value intermediates for multiple synthetic transformations.

  8. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
    9. Full Papers
    10. Preview
    1. Metal–Organic Frameworks

      Direct Observation of Molecular-Level Template Action Leading to Self-Assembly of a Porous Framework (pages 3926–3932)

      Sneha R. Bajpe, Christine E. A. Kirschhock, Alexander Aerts, Eric Breynaert, Gregory Absillis, Tatjana N. Parac-Vogt, Lars Giebeler and Johan A. Martens

      Article first published online: 16 MAR 2010 | DOI: 10.1002/chem.200903239

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      The template is the key: A strong noncovalent interaction between Cu2+ ions and Keggin-type heteropolyacids leads to spatial organization that can be exploited for direct templating of a metal–organic framework (see figure; BTC=1,3,5-benzenetricarboxylic acid).

    2. Rotaxanes

      A Conjugated Thiophene-Based Rotaxane: Synthesis, Spectroscopy, and Modeling (pages 3933–3941)

      Leszek Zalewski, Michael Wykes, Sergio Brovelli, Massimo Bonini, Thomas Breiner, Marcel Kastler, Florian Dötz, David Beljonne, Harry L. Anderson, Franco Cacialli and Paolo Samorì

      Article first published online: 12 MAR 2010 | DOI: 10.1002/chem.200903353

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      A chemical workout: A dithiophene rotaxane and its reference dumbbell were synthesized by means of aqueous Suzuki coupling (see scheme). The structure of this encapsulated dithiophene was confirmed by 1D and 2D NMR spectroscopy as well as molecular dynamics calculations. Photophysical properties of both systems were also investigated.

    3. Imaging Agents

      A Triphenylphosphonium-Functionalised Cyclometalated Platinum(II) Complex as a Nucleolus-Specific Two-Photon Molecular Dye (pages 3942–3950)

      Chi-Kin Koo, Leo K.-Y. So, Ka-Leung Wong, Yu-Man Ho, Yun-Wah Lam, Michael H.-W. Lam, Kwok-Wai Cheah, Chopen Chan-Wut Cheng and Wai-Ming Kwok

      Article first published online: 22 MAR 2010 | DOI: 10.1002/chem.200902919

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      In a flash! A cyclometalated PtII complex has been synthesised from a specially designed cyclometalating ligand with a terminal triphenylphosphonium moiety. The complex exhibits two-photon-induced luminescence upon excitation at 700 nm from a Ti:sapphire laser and is able to selectively label the cell nucleolus (see arrows in scheme).

    4. Photocrosslinking

      A Rigid Dinuclear Ruthenium(II) Complex as an Efficient Photoactive Agent for Bridging Two Guanine Bases of a Duplex or Quadruplex Oligonucleotide (pages 3951–3961)

      Stéphane Rickling, Liana Ghisdavu, Frédéric Pierard, Pascal Gerbaux, Mathieu Surin, Pierre Murat, Eric Defrancq, Cécile Moucheron and Andrée Kirsch-De Mesmaeker

      Article first published online: 19 FEB 2010 | DOI: 10.1002/chem.200902817

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      Photoactive agents: The dinuclear [(tap)2Ru(tpac)Ru(tap)2]4+ (TAP= 1,4,5,8-tetraazaphenanthrene, TPAC= tetrapyridoacridine) complex is very efficient at photobridging two guanine (G) bases (see illustration), in which either each base belongs to a strand of a duplex, or both bases belong to a single strand of a telomeric sequence. In the duplex, the highest photocrosslinking yield occurs when the G units are separated by a distance corresponding to three to four base pairs.

    5. Ion–Molecule Reactions

      Ion–Molecule Reactions of “Rollover” Cyclometalated [Pt(bipy−H)]+ (bipy=2,2′-bipyridine) with Dimethyl Ether in Comparison with Dimethyl Sulfide: An Experimental/Computational Study (pages 3962–3969)

      Burkhard Butschke, Shadan Ghassemi Tabrizi and Helmut Schwarz

      Article first published online: 23 FEB 2010 | DOI: 10.1002/chem.200902742

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      Oxygen versus sulfur: The gas-phase ion–molecule reactions of “rollover” cyclometalated [Pt(bipy−H)]+ with (CH3)2X (X=O, S) differ significantly in their product distributions (see scheme). In particular, for (CH3)2O there is no reaction equivalent to the oxidative coupling of two methyl groups to generate C2H4 (“dehydrosulfurization”). Common to both substrates is the initial Pt-mediated C[BOND]H bond activation. Mechanistic details were uncovered by DFT calculations and extensive labeling experiments.

    6. Electrochemical Oxidation

      Electrochemical Deallylation of α-Allyl Cyclic Amines and Synthesis of Optically Active Quaternary Cyclic Amino Acids (pages 3970–3982)

      Peter G. Kirira, Masami Kuriyama and Osamu Onomura

      Article first published online: 19 FEB 2010 | DOI: 10.1002/chem.200903512

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      Oxidative C[BOND]C guillotine: The efficient electrochemical oxidation of α-allylated and α-benzylated N-acylated amines has been developed and easily affords the methoxy products with up to 76 % yield (see scheme). This technique was successfully applied to the synthesis of optically active N-acylated α-alkyl-α-amino acid esters with up to 99 % ee.

    7. N-Heterocyclic Carbenes

      [(NHC)(NHCewg)RuCl2(CHPh)] Complexes with Modified NHCewg Ligands for Efficient Ring-Closing Metathesis Leading to Tetrasubstituted Olefins (pages 3983–3993)

      Volodymyr Sashuk, Lars H. Peeck and Herbert Plenio

      Article first published online: 22 FEB 2010 | DOI: 10.1002/chem.200903275

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      So clear, so shining, and so evident: Optimized catalysts for RCM reactions of sterically hindered olefins with unprecedented activity were synthesized. The tagging of NHC ligands with a fluorophore dye provides information on the mechanism of the initiation reaction (see scheme) leading to the spatial separation of the fluorophore and ruthenium.

    8. Synthetic Receptors

      Synthesis and Self-Aggregation of Enantiopure and Racemic Molecular Tweezers Based on the Bicyclo[3.3.1]nonane Framework (pages 3994–4002)

      Carl-Johan Wallentin, Torbjörn Wixe, Ola F. Wendt, Karl-Erik Bergquist and Kenneth Wärnmark

      Article first published online: 24 FEB 2010 | DOI: 10.1002/chem.200902925

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      Enclosed in aromatic arms: Both racemic and enantiomerically pure molecular tweezers based on the rigid, C2-symmetric bicyclo[3.3.1]nonane framework were synthesised. Self-association studies revealed that homochiral fidelity is present in the solid state (see picture) but not in solution (CDCl3) for the racemic tweezers.

    9. Asymmetric Hydrogenation

      Iridium-Catalyzed Asymmetric Hydrogenation of Imines (pages 4003–4009)

      Alejandro Baeza and Andreas Pfaltz

      Article first published online: 10 MAR 2010 | DOI: 10.1002/chem.200903418

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      Faster, higher, stronger: A wide range of iridium complexes with chiral oxazoline-based N,P ligands was evaluated in the asymmetric hydrogenation of imines. Three efficient catalysts emerged from this study that gave excellent results in the asymmetric hydrogenation of acetophenone N-arylimines and related substrates. In terms of enantioselectivity, catalytic activity, and turnover numbers, these readily accessible complexes rival the best catalysts reported to date for this transformation (see scheme).

    10. Cross-Coupling Reactions

      Rational Exploration of N-Heterocyclic Carbene (NHC) Palladacycle Diversity: A Highly Active and Versatile Precatalyst for Suzuki–Miyaura Coupling Reactions of Deactivated Aryl and Alkyl Substrates (pages 4010–4017)

      Guang-Rong Peh, Eric Assen B. Kantchev, Jun-Cheng Er and Jackie Y. Ying

      Article first published online: 19 FEB 2010 | DOI: 10.1002/chem.200902842

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      Suzuki on ice! A novel, hybrid precatalyst comprising 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) and a cyclopalladated acetanilide (see figure) mediates sp2–sp2, sp2–sp3, sp3–sp2 and sp3–sp3 Suzuki–Miyaura reactions at room temperature and even at 0 °C. The complex was discovered by screening a library of rationally diverse N-heterocyclic carbene palladacycles prepared by the simple heating of palladacycle acetate dimers and IPr⋅HCl in DMSO in air.

    11. Biocatalysis

      Preparation and Characterization of a Bifunctional Aldolase/Kinase Enzyme: A More Efficient Biocatalyst for C[BOND]C Bond Formation (pages 4018–4030)

      Laura Iturrate, Israel Sánchez-Moreno, Isabel Oroz-Guinea, Jesús Pérez-Gil and Eduardo García-Junceda

      Article first published online: 2 MAR 2010 | DOI: 10.1002/chem.200903096

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      When one plus one is more than two: An engineered bifunctional enzyme can catalyze aldol addition reactions by using dihydroxyacetone (DHA; see scheme) as an initial ketone donor. This new enzyme is a more affordable, stable, and efficient biocatalyst than the multienzyme system composed of the free parent enzymes.

    12. Asymmetric Synthesis

      Asymmetric Synthesis of Bicyclic Diol Derivatives through Metal and Enzyme Catalysis: Application to the Formal Synthesis of Sertraline (pages 4031–4036)

      Patrik Krumlinde, Krisztián Bogár and Jan-E. Bäckvall

      Article first published online: 1 MAR 2010 | DOI: 10.1002/chem.200903114

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      So pure: Enantiomerically pure bicyclic diols (R,R)-1, their acetate derivatives A, and chiral hydroxy ketones B are useful synthetic intermediates for the preparation of various biologically active compounds. These synthetic intermediates are obtained through enzyme and ruthenium catalysis. The utility of these intermediates is demonstrated by a formal synthesis of sertraline (see scheme). CALB=Candida antarctica lipase B.

    13. Metal–Organic Frameworks

      The Construction of Open GdIII Metal–Organic Frameworks Based on Methanetriacetic Acid: New Objects with an Old Ligand (pages 4037–4047)

      Laura Cañadillas-Delgado, Tomás Martín, Oscar Fabelo, Jorge Pasán, Fernando S. Delgado, Francesc Lloret, Miguel Julve and Catalina Ruiz-Pérez

      Article first published online: 23 FEB 2010 | DOI: 10.1002/chem.200903053

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      The tripod of stability: First examples that illustrate how the tripodal ligand methanetriacetic acid promotes interesting and rare 63 networks with GdIII ions: a two-dimensional 63-hcb net (1), a two-dimensional (6,3)-connected binodal (43)(466683)-kgd net (2) and a (6,6)-connected binodal nia-net (3). Magneto-structural data for digadolinium(III) motifs with carboxylate-type ligands indicate a relationship between the nature of the magnetic coupling and the type of bridge connecting the GdIII centers.

    14. Silanes

      Preparation of “Si-Centered” Chiral Silanes by Direct α-Lithiation of Methylsilanes (pages 4048–4062)

      Christian Däschlein, Viktoria H. Gessner and Carsten Strohmann

      Article first published online: 24 FEB 2010 | DOI: 10.1002/chem.200902551

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      Silicon-chiral silanes: The synthesis of stereochemically pure silanes with a stereogenic silicon center is a challenging task in modern synthetic chemistry. Two new methods for their preparation are presented herein, one based on the selective α-lithiation of alkyl-substituted silicon-chiral disilanes, trisilanes, and silagermanes, and the other based on diastereoselective α-lithiation of an initially non-silicon-chiral silane (see diagram).

    15. Porphyrinoids

      Highly Pure Synthesis, Spectral Assignments, and Two-Photon Properties of Cruciform Porphyrin Pentamers Fused with Benzene Units (pages 4063–4074)

      Hiroki Uoyama, Kil Suk Kim, Kenji Kuroki, Jae-Yoon Shin, Toshi Nagata, Tetsuo Okujima, Hiroko Yamada, Noboru Ono, Dongho Kim and Hidemitsu Uno

      Article first published online: 19 FEB 2010 | DOI: 10.1002/chem.200903196

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      Chemical confusion! Cruciform porphyrin pentamers fused with benzene units have been prepared from bicyclo[2.2.2]octadiene-fused porphyrin pentamers by the retro-Diels–Alder reaction in quantitative yields. Spectral assignments and two-photon absorption properties (see figure) of fully π-conjugated pentamers were discussed.

    16. Suzuki–Miyaura Cross-Coupling

      Dichloro-Bis(aminophosphine) Complexes of Palladium: Highly Convenient, Reliable and Extremely Active Suzuki–Miyaura Catalysts with Excellent Functional Group Tolerance (pages 4075–4081)

      Jeanne L. Bolliger and Christian M. Frech

      Article first published online: 24 FEB 2010 | DOI: 10.1002/chem.200903309

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      Effective Suzuki catalysts! Dichlorobis(aminophosphine)palladium complexes are extremely active and reliable Suzuki catalysts with excellent functional group tolerance. Aminophosphines promote the formation of palladium nanoparticles (see scheme). Decomposition products are dicyclohexylphosphinate, cyclohexylphosphonate, and phosphate, which can easily be separated from the coupling products.

    17. Organolithium Compounds

      Asymmetric Substitutions of 2-Lithiated N-Boc-piperidine and N-Boc-azepine by Dynamic Resolution (pages 4082–4090)

      Iain Coldham, Sophie Raimbault, David T. E. Whittaker, Praful T. Chovatia, Daniele Leonori, Jignesh J. Patel and Nadeem S. Sheikh

      Article first published online: 19 FEB 2010 | DOI: 10.1002/chem.200903059

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      Dynamic resolutions: Organolithiums formed by deprotonation of N-Boc-piperidine and N-Boc-azepine can be resolved in the presence of diamino-alkoxide ligands (see scheme). Both dynamic thermodynamic resolution and dynamic kinetic resolution are possible, leading to the highly enantioselective synthesis of 2-substituted piperidines and azepines.

    18. Endocannabinoid Synthesis

      Design and Synthesis of (13S)-Methyl-Substituted Arachidonic Acid Analogues: Templates for Novel Endocannabinoids (pages 4091–4099)

      Demetris P. Papahatjis, Victoria R. Nahmias, Spyros P. Nikas, Marion Schimpgen and Alexandros Makriyannis

      Article first published online: 24 FEB 2010 | DOI: 10.1002/chem.200902880

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      Chiral lipids: We report the design and enantioselective synthesis of two (13S)-methyl-substituted arachidonic acid derivatives (see graphic) that have served as templates in the development of novel endocannabinoid analogues. One of the new analogues has remarkably high affinity for the CB1 cannabinoid receptor.

    19. Pericyclic Reactions

      Synthesis of Highly Substituted Cyclobutane Fused-Ring Systems from N-Vinyl β-Lactams through a One-Pot Domino Process (pages 4100–4109)

      Lawrence L. W. Cheung and Andrei K. Yudin

      Article first published online: 23 FEB 2010 | DOI: 10.1002/chem.200902748

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      Fused into one: Fused aminocyclobutanes have been prepared from N-vinyl β-lactams in a highly stereoselective manner (see scheme; R=alkyl, aryl). The reaction mechanism goes by a domino one-pot [3,3]-sigmatropic/6π-electrocyclisation process. The aminocyclobutanes isolated can have up to three contiguous stereocentres and four fused rings.

    20. C[BOND]H Activation

      Preferential Activation of Primary C[BOND]H Bonds in the Reactions of Small Alkanes with the Diatomic MgO+. Cation (pages 4110–4119)

      Detlef Schröder, Jana Roithová, Esmail Alikhani, Karolina Kwapien and Joachim Sauer

      Article first published online: 24 FEB 2010 | DOI: 10.1002/chem.200902373

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      Control freak! Pronounced kinetic control in the C[BOND]H bond activation of small alkanes by gaseous MgO+. leads to a preferential attack of primary C[BOND]H bonds (see scheme). MgO+. is different to transition-metal oxide cations, which prefer to attack secondary C[BOND]H bonds.

    21. Nanostructures

      Noncovalent Assembly of Picket-Fence Porphyrins on Nitrogen-Doped Carbon Nanotubes for Highly Efficient Catalysis and Biosensing (pages 4120–4126)

      Wenwen Tu, Jianping Lei, Guoqiang Jian, Zheng Hu and Huangxian Ju

      Article first published online: 16 FEB 2010 | DOI: 10.1002/chem.200902874

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      Biofunctional materials: A picket-fence porphyrin was assembled on nitrogen-doped multiwalled carbon nanotubes (CNx MWNTs) through Fe[BOND]N coordination for highly efficient catalysis. By using electrochemical methods, the presence of CNx MWNTs led to the direct formation of a high-valent iron(IV)–porphyrin unit, which produced excellent catalytic activity toward the oxidation of sulfite ions (see picture). A biosensor for sulfite ions with a good performance was thus proposed.

  9. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Review
    8. Communications
    9. Full Papers
    10. Preview
    1. You have free access to this content
      Preview: Chem. Eur. J. 14/2010 (page 4133)

      Article first published online: 26 MAR 2010 | DOI: 10.1002/chem.201090062

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