A “Neck-Formation” Strategy for an Antiquenching Magnetic/Upconversion Fluorescent Bimodal Cancer Probe (pages 11254–11260)
Feng Chen, Shengjian Zhang, Prof. Wenbo Bu, Xiaohang Liu, Yu Chen, Qianjun He, Min Zhu, Prof. Lingxia Zhang, Liangping Zhou, Prof. Weijun Peng and Prof. Jianlin Shi
Article first published online: 16 AUG 2010 | DOI: 10.1002/chem.201000525
Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF4:Er,Yb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general “neck-formation” strategy, forming a size-controlled, Cd2+- and Gd3+-free, silica-shielded, magnetic upconversion fluorescent oligomer (SMUFO), bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T2-weighted magnetic resonance enhanced effect (see graphic).