New Molecular Markers for Prostate Tumor Imaging: A Study on 2-Methylene Substituted Fatty Acids as New AMACR Inhibitors (pages 10144–10150)
Dr. Agnieszka Morgenroth, Elizaveta A. Urusova, Cornelia Dinger, Ehab Al-Momani, Dr. Thomas Kull, Prof. Gerhard Glatting, Dr. Holm Frauendorf, Dr. Olaf Jahn, Prof. Felix M. Mottaghy, Prof. Sven N. Reske and Dr. Boris D. Zlatopolskiy
Version of Record online: 2 AUG 2011 | DOI: 10.1002/chem.201003176
Marking tumors: 2-Methylenacyl-coenzyme A thioesters inhibit α-methyl-CoA-racemase (AMACR) in the micromolar range (see figure). Radioiodinated acrylic acid 131I-1 accumulates more efficiently in AMACR+ (shown in green) than AMACR− (shown in purple) cell lines. In contrast to AMACR-knockout mutant cells, significant protein-bound radioactivity is detected in AMACR-expressing cells.