Unravelling the Reaction Path of Rhodium–MonoPhos-Catalysed Olefin Hydrogenation (pages 12683–12695)
Dr. Elisabetta Alberico, Priv.-Doz. Dr. Wolfgang Baumann, Prof. Dr. Johannes G. de Vries, Dr. Hans-Joachim Drexler, Prof. Dr. Serafino Gladiali, Prof. Dr. Detlef Heller, Huub J. W. Henderickx and Dr. Laurent Lefort
Article first published online: 28 SEP 2011 | DOI: 10.1002/chem.201101793
Dimers are forever: Reaction intermediates around the catalytic cycle of the asymmetric hydrogenation of methyl (Z)-2-acetamidocinnamate by [Rh(MonoPhos)2(nbd)]SbF6 (nbd=bicyclo[2.2.1]hepta-2,5-diene) catalyst (see scheme) were detected by using 1H, 31P and 103Rh NMR spectroscopy and ESI-MS. The asymmetric hydrogenation appears to follow a Halpern-like mechanism.