Aryl–Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides (pages 13230–13239)
Dr. Christine M. Boehner, Elizabeth C. Frye, Kieron M. G. O'Connell, Dr. Warren R. J. D. Galloway, Dr. Hannah F. Sore, Dr. Patricia Garcia Dominguez, Dr. David Norton, Dr. David G. Hulcoop, Dr. Martin Owen, Dr. Gillian Turner, Dr. Claire Crawford, Dr. Helen Horsley and Dr. David R. Spring
Article first published online: 11 OCT 2011 | DOI: 10.1002/chem.201102285
An attractive alternative: Biaryl synthesis, involving the fluoride-free cross-coupling of aryl bromides with aryldisiloxanes, is reported. This methodology is an attractive alternative to the traditional transition-metal-catalysed routes typically used to generate molecules containing the privileged biaryl scaffold (see scheme). As such, it is anticipated that this cross-coupling strategy could prove valuable in a wide synthetic context.