Relative and Absolute Configuration of Vatiparol (1 mg): A Novel Anti-inflammatory Polyphenol (pages 5213–5221)
Dr. Hui Ming Ge, Han Sun, Dr. Nan Jiang, Yan Hua Qin, Huan Dou, Tong Yan, Prof. Ya Yi Hou, Prof. Christian Griesinger and Prof. Ren Xiang Tan
Version of Record online: 20 MAR 2012 | DOI: 10.1002/chem.201104078
Only one milligram: Natural products offer opportunities for the discovery of molecules with potential pharmaceutical and agrochemical activities. We have developed a methodology that combines residual dipolar coupling based NMR spectroscopy and motif-inspired biological assessment (see figure). This allowed the identification of the bioactivity and the relative and absolute configurations of vatiparol from V. parvifolia using a 1 mg sample.