Unraveling the Mechanism of the Photodeprotection Reaction of 8-Bromo- and 8-Chloro-7-hydroxyquinoline Caged Acetates (pages 6854–6865)
Jiani Ma, Adam C. Rea, Dr. Huiying An, Dr. Chensheng Ma, Dr. Xiangguo Guan, Dr. Ming-De Li, Tao Su, Chi Shun Yeung, Kyle T. Harris, Dr. Yue Zhu, Jameil L. Nganga, Dr. Olesya D. Fedoryak, Dr. Timothy M. Dore and Dr. David Lee Phillips
Article first published online: 18 APR 2012 | DOI: 10.1002/chem.201200366
The water-mediated triplet excited state deprotection reaction of 8-bromo- and 8-chloro-7-hydroxyquinoline caged acetate (BHQ-OAc) in water-rich neutral solutions was investigated through photochemical product outcome studies and nanosecond time-resolved spectroscopic measurements. Combined with density functional theory calculations, a detailed photodeprotection mechanism in neutral aqueous solution was deduced (see scheme).