Yanyan Qu, Jianxi Liu, Dr. Kaiguang Yang, Dr. Zhen Liang, Prof. Dr. Lihua Zhang and Prof. Yukui Zhang
Glycopeptides captured! Boronic acid functionalized core–shell polymer nanoparticles were synthesized to enrich glycopeptides. The core and shell were formed by distillation precipitation polymerization and free-radical polymerization, respectively (see scheme; AIBN=2,2′-azobisisobutyronitrile, MAA=methacrylic acid, MBA=methylenebisacrylamide, VPBA=4-vinylphenylboronic acid). The preparation of such nanoparticles is facile, time-saving, and the enrichment selectivity for glycopeptides is superior to the commercially available meta-aminophenylboronic acid agarose.