Amycolamicin: A Novel Broad-Spectrum Antibiotic Inhibiting Bacterial Topoisomerase (pages 15772–15781)
Dr. Ryuichi Sawa, Dr. Yoshiaki Takahashi, Dr. Hideki Hashizume, Dr. Kazushige Sasaki, Dr. Yoshimasa Ishizaki, Maya Umekita, Dr. Masaki Hatano, Hikaru Abe, Dr. Takumi Watanabe, Naoko Kinoshita, Yoshiko Homma, Chigusa Hayashi, Kunio Inoue, Syunichi Ohba, Toru Masuda, Dr. Masayuki Arakawa, Dr. Yoshihiko Kobayashi, Dr. Masa Hamada, Dr. Masayuki Igarashi, Dr. Hayamitsu Adachi, Dr. Yoshio Nishimura and Dr. Yuzuru Akamatsu
Version of Record online: 5 NOV 2012 | DOI: 10.1002/chem.201202645
Equilibrium structure: Amycolamicin (AMM) was discovered as a new antibiotic and its absolute structure was determined. The pyranose ring named as amykitanose undergoes anomerization in methanol. AMM is effective against methicillin-resistant Staphylococcus aureus and its strains, which are resistant to known DNA gyrase inhibitors. AMM is a potent and selective inhibitor of DNA gyrase and it does not inhibit human topoisomerase II (see figure).