Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from Microcystis aeruguinosa PCC 7806 (pages 4596–4601)
Dr. Malika Makhlouf Brahmi, Dr. Cyril Portmann, Danilo D'Ambrosio, Dr. Tom M. Woods, Damiano Banfi, Patrick Reichenbach, Laeticia Da Silva, Emilie Baudat, Dr. Gerardo Turcatti, Prof. Dr. Joachim Lingner and Prof. Dr. Karl Gademann
Version of Record online: 31 JAN 2013 | DOI: 10.1002/chem.201203296
Out in the green! Screening cyanobacteria for inhibitors of telomerase led to the identification of sulfoquinovosyl diacylglycerols as the active species (see figure). A structure–activity relationship study highlighted the importance of the lipid chains for the inhibition of telomerase, and a certain length was found to be essential for biological activity.