Total Synthesis of Gelsemiol (pages 2589–2591)
Patrick Burch, Massimo Binaghi, Manuel Scherer, Corinna Wentzel, David Bossert, Dr. Luc Eberhardt, Dr. Markus Neuburger, Prof. Dr. Peter Scheiffele and Prof. Dr. Karl Gademann
Article first published online: 10 JAN 2013 | DOI: 10.1002/chem.201203746
Let it grow! The neuritogenic iridoid gelsemiol has been prepared in synthetic form by a radical cascade and skeletal rearrangement. This compound accelerates the differentiation of neurons and growth of neuritis (see scheme).