Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging (pages 12363–12370)
Lingfei Yang, Dr. Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Prof. Dr. Jun-Long Zhang, Prof. Dr. Ping Xu, Dr. Lan Yuan and Prof. Dr. Lei Liang
Version of Record online: 21 JUL 2016 | DOI: 10.1002/chem.201601499
Better probes by design: A pyridazinone/phthalazinone library of one- and two-photon emissive probes for use in live-cell and brain-tissue imaging (see figure) was constructed. The electronic states of the N-substituents of the pyridazinone/phthalazinone moieties effectively modulate the photophysical properties of the fluorescent probes, and the terminal groups on the alkyl chain determine the lipophilicity and subcellular organelle selectivity.