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ChemInform Abstract: Synthesis of Multifunctionalized Building Blocks via Vinylogous Addition of Chan′s Diene to Carbonyl and Carbonyl-Related Electrophiles, Mediated by Molecular Iodine.



Vinylogous addition of Chan′s diene towards aldehydes, ketones, acetals as well as imines proceeds with excellent γ-selectivity to give β-keto esters bearing hydroxy (III), (VII), alkoxy (IX) as well as amino groups (V), resp., in good yields.