ChemInform Abstract: Organocatalytic Enantioselective Michael Addition of Malonic Acid Half-Thioesters to β-Nitroolefins: From Mimicry of Polyketide Synthases to Scalable Synthesis of γ-Amino Acids.

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Abstract

The amide (ALK) efficiently promotes the asymmetric coupling of nitroolefins with the thioester (II) giving adducts of type (III)/(VII) with high enantioselectivity.

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