Preparative resolution of the enantiomers of Tert-leucine derivatives by simulated moving bed chromatography
Article first published online: 11 APR 2002
Copyright © 2002 Wiley-Liss, Inc.
Volume 14, Issue 4, pages 313–317, 2002
How to Cite
Francotte, E., Leutert, T., La Vecchia, L., Ossola, F., Richert, P. and Schmidt, A. (2002), Preparative resolution of the enantiomers of Tert-leucine derivatives by simulated moving bed chromatography. Chirality, 14: 313–317. doi: 10.1002/chir.10042
- Issue published online: 11 APR 2002
- Article first published online: 11 APR 2002
- Manuscript Accepted: 3 SEP 2001
- Manuscript Received: 5 JUL 2001
- simulated-moving-bed (SMB);
- enantiomer separation;
- chiral stationary phases;
The enantiomers of two different derivatives of tert-leucine were separated by continuous chromatography on chiral stationary phases applying the simulated moving bed technique. About 1 kg of racemic N-carbobenzoxy-tert-leucine was resolved on the cellulose-based phase Chiralcel OD using a mixture of heptane/ethanol and 0.1% of trifluoroacetic acid modifier as the mobile phase, while 520 g of the N-Boc-tert-leucine-benzylester was resolved on the amylose-based phase Chiralpak AD with a mixture of heptane/2-propanol as the mobile phase. In both instances the corresponding enantiomers were obtained in high yield and high optical purity. Chirality 14:313–317, 2002. © 2002 Wiley-Liss, Inc.