Generation of molecular chiral asymmetry through stirred crystallization
Article first published online: 11 APR 2002
Copyright © 2002 Wiley-Liss, Inc.
Volume 14, Issue 4, pages 284–287, 2002
How to Cite
Durand, D. J., Kondepudi, D. K., Moreira Jr., P. F. and Quina, F. H. (2002), Generation of molecular chiral asymmetry through stirred crystallization. Chirality, 14: 284–287. doi: 10.1002/chir.10044
- Issue published online: 11 APR 2002
- Article first published online: 11 APR 2002
- Manuscript Accepted: 31 JUL 2001
- Manuscript Received: 3 APR 2001
- National Science Foundation. Grant Number: CHE-9527095
- spontaneous asymmetry generation;
- chiral symmetry breaking
In our earlier work we established that stirred crystallization of achiral compounds that crystallize in enantiomeric forms result in spontaneous chiral symmetry breaking. The asymmetry thus spontaneously generated is confined to the solid state. In this article, we present a case in which the crystal enantiomeric excess (CEE) can be converted to molecular enantiomeric excess (EE) through a solid state reaction which relates the enantiomeric form of the crystal to the enantiomeric form of the product. Such a process not only provides a means of detecting the CEE generated in stirred crystallization but it is also a means through which chiral asymmetry generated spontaneously is “propagated” to generate chiral compounds with enantiomeric excess. Chirality 14:284–287, 2002. © 2002 Wiley-Liss, Inc.