Regular Article

Gas chromatographic separation of saturated aliphatic hydrocarbon enantiomers on permethylated β-cyclodextrin

  1. Uwe J. Meierhenrich1,2,*,
  2. Mai-Julie Nguyen2,
  3. Bernard Barbier2,
  4. André Brack2,
  5. Wolfram H.-P. Thiemann1

Article first published online: 9 JUL 2003

DOI: 10.1002/chir.10269

Issue

Chirality

Chirality

Special Issue: Proceedings from the Fourteenth International Symposium On Chiral Discrimination, Hamburg, Germany, 2002

Volume 15, Issue S1, pages S13–S16, 2003

Additional Information

How to Cite

Meierhenrich, U. J., Nguyen, M.-J., Barbier, B., Brack, A. and Thiemann, W. H.-P. (2003), Gas chromatographic separation of saturated aliphatic hydrocarbon enantiomers on permethylated β-cyclodextrin. Chirality, 15: S13–S16. doi: 10.1002/chir.10269

Author Information

  1. 1

    University of Bremen, Department of Physical Chemistry, Bremen, Germany

  2. 2

    Centre de Biophysique Moléculaire, Orléans, France

*University of Bremen, Dept. Physical Chemistry, FB 02, Leobener Str., D-28359 Bremen, Germany

Publication History

  1. Issue published online: 9 JUL 2003
  2. Article first published online: 9 JUL 2003
  3. Manuscript Accepted: 7 APR 2003
  4. Manuscript Received: 16 DEC 2002

Funded by

  • Deutsche Forschungsgemeinschaft DFG. Grant Numbers: ME 1781/4-1, 283329 H
  • Bonn
  • LeStudium®, Orléans
  • European Union
  • CNES
  • FNAD
  • Région Centre
  • Département du Cher

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Keywords:

  • alkanes;
  • chirality;
  • enantiomer separation;
  • enantioselective gas chromatography;
  • olefins;
  • Rosetta;
  • trialkylmethanes

Abstract

Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryostat-controlled gas chromatograph is described. The use of a cryogenic system allows the improvement of separations for various chiral aliphatic hydrocarbons. The molecular cyclodextrin-based mechanism of the achieved enantiomeric separations is discussed briefly. Possible applications of this analytical technique are summarized, with special emphasis on the planned enantiomeric separation experiment on a cometary nucleus. Chirality 15:S13–S16, 2003. © 2003 Wiley-Liss, Inc.

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