Application of lipases in kinetic resolution of racemates

Authors

  • Ashraf Ghanem,

    Corresponding author
    1. Department of Organic Chemistry, University of Geneva, Geneva, Switzerland
    2. Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03-65), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    • Pharmaceutical Analysis Laboratory, Biological and Medical Research Dept. (MBC-03-65), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia
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  • Hassan Y. Aboul-Enein

    1. Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03-65), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Abstract

Lipases have been well established as valuable catalysts in organic synthesis. This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed kinetic resolution of racemates as a versatile method for the separation of enantiomers. The literature search dates back to the last five years and covers some comprehensive examples. The main emphasis is on the use of lipases in organic solvents. Chirality 17:1–15, 2005. © 2004 Wiley-Liss, Inc.

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