Development of the Travelling Wave Bioreactor – A Concept Study

Authors

  • Stephan C. Kaiser,

    Corresponding author
    1. Zurich University of Applied Sciences, Institute of Biotechnology, Grüental, 8820 Wädenswil, Switzerland
    • Zurich University of Applied Sciences, Institute of Biotechnology, Grüental, 8820 Wädenswil, Switzerland
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  • Prof. Matthias Kraume,

    1. Technische Universität Berlin, Chair of Chemical and Process Engineering, Straße des 17. Juni 135, 10623 Berlin, Germany
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  • Prof. Dieter Eibl

    1. Zurich University of Applied Sciences, Institute of Biotechnology, Grüental, 8820 Wädenswil, Switzerland
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Abstract

This study presents the concept of the travelling wave single-use bioreactor, based on an orbitally shaken, annular-shaped vessel. A numerical model was developed for early design studies in order to reduce the number of prototypes. The flow characteristics in two different vessel shapes were investigated. It was shown that the orbital motion combined with the toroidal shape of the bioreactor create the desired wave characteristics in the contents of the vessel.

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