Integrated Clinical Scale Manufacturing System for Cellular Products Derived by Magnetic Cell Separation, Centrifugation and Cell Culture (pages 103–110)
Dr. Michael Apel, Dr. Mareke Brüning, Markus Granzin, Mike Essl, Juliane Stuth, Jessica Blaschke, Iris Spiegel, Sabine Müller, Eiad Kabaha, Elmar Fahrendorff, Stefan Miltenyi, Dr. Jürgen Schmitz, Dr. Dirk Balshüsemann and Volker Huppert
Article first published online: 25 JAN 2013 | DOI: 10.1002/cite.201200175
A new platform technology for cell processing is introduced that facilitates fully automated manufacturing of cellular products for clinical applications in a single-use tubing set. This functionally closed disposable integrates multiple workflows like cell washing, labeling, separation and cultivation. Thereby, it may allow advancing innovative research into next generation cellular therapies for routine use.